Replication fork movement sets chromatin loop size and origin choice in mammalian cells

Sylvain Courbet, Sophie Gay, Nausica Arnoult, Gerd Wronka, Mauro Anglana, Olivier Brison and Michelle Debatisse ()
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Sylvain Courbet: Institut Curie, 26 rue d’Ulm, 75248 Paris, France
Sophie Gay: Institut Curie, 26 rue d’Ulm, 75248 Paris, France
Nausica Arnoult: Institut Curie, 26 rue d’Ulm, 75248 Paris, France
Gerd Wronka: Institut Curie, 26 rue d’Ulm, 75248 Paris, France
Mauro Anglana: Institut Curie, 26 rue d’Ulm, 75248 Paris, France
Olivier Brison: Institut Curie, 26 rue d’Ulm, 75248 Paris, France
Michelle Debatisse: Institut Curie, 26 rue d’Ulm, 75248 Paris, France

Nature, 2008, vol. 455, issue 7212, 557-560

Abstract: Chromatin kept in the loop In mammalian cells, the genome undergoes one round of replication per cell cycle. Many origins of replication are never fired, but they serve as a reservoir to be activated if part of the genome is in danger of not being replicated — when progression of a replication fork stalls, for example. Courbet et al. show that latent origins can also be activated by slowing of replication fork progression, and this influences the size of the chromatin loop. In addition, they find that origins located nearby the attachment point of chromatin loops to the nuclear matrix are preferentially activated in the next cell cycle.

Date: 2008
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DOI: 10.1038/nature07233

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