FcRn-mediated antibody transport across epithelial cells revealed by electron tomography

Wanzhong He, Mark S. Ladinsky, Kathryn E. Huey-Tubman, Grant J. Jensen, J. Richard McIntosh and Pamela J. Björkman ()
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Wanzhong He: Division of Biology 114-96 and,
Mark S. Ladinsky: Boulder Laboratory for 3D Electron Microscopy of Cells, Cellular and Developmental Biology, University of Colorado, Boulder, Colorado 80309, USA
Kathryn E. Huey-Tubman: Division of Biology 114-96 and,
Grant J. Jensen: Division of Biology 114-96 and,
J. Richard McIntosh: Boulder Laboratory for 3D Electron Microscopy of Cells, Cellular and Developmental Biology, University of Colorado, Boulder, Colorado 80309, USA
Pamela J. Björkman: Division of Biology 114-96 and,

Nature, 2008, vol. 455, issue 7212, 542-546

Abstract: Delivering maternal antibodies The Fc receptor of neonates (FcRn) mediates the apical-to-basolateral transcytosis of immunoglobulin G (IgG) across epithelial cells so that newborns are able to receive maternal antibodies. In this study Her et al. use electron tomography to visualize the transport of IgG during this process with a resolution of 4–6 nm. Individual FcRn ligands were identified inside intracellular organelles using a new gold enlargement technique compatible with high pressure frozen samples. The transcytosis pathways revealed show labelled-Fc moving through networks of vesicles as it migrates from the apical to basolateral surface.

Date: 2008
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DOI: 10.1038/nature07255

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