CDK targets Sae2 to control DNA-end resection and homologous recombination

Pablo Huertas, Felipe Cortés-Ledesma, Alessandro A. Sartori, Andrés Aguilera and Stephen P. Jackson ()
Additional contact information
Pablo Huertas: The Wellcome Trust and Cancer Research UK Gurdon Institute, University of Cambridge, Tennis Court Road, Cambridge CB2 1QN, UK
Felipe Cortés-Ledesma: Centro Andaluz de Biología Molecular y Medicina Regenerativa CABIMER, Universidad de Sevilla-CSIC, Avenida Américo Vespucio s/n, 41092 Sevilla, Spain
Alessandro A. Sartori: The Wellcome Trust and Cancer Research UK Gurdon Institute, University of Cambridge, Tennis Court Road, Cambridge CB2 1QN, UK
Andrés Aguilera: Centro Andaluz de Biología Molecular y Medicina Regenerativa CABIMER, Universidad de Sevilla-CSIC, Avenida Américo Vespucio s/n, 41092 Sevilla, Spain
Stephen P. Jackson: The Wellcome Trust and Cancer Research UK Gurdon Institute, University of Cambridge, Tennis Court Road, Cambridge CB2 1QN, UK

Nature, 2008, vol. 455, issue 7213, 689-692

Abstract: DNA repair: pathways in balance DNA can be repaired by two fundamentally different mechanisms, depending on whether a homologous template is available or not. Given that DNA is duplicated in S phase, homologous recombination is restricted to S and G2 phases of the cell cycle. The activity of cyclin-dependent kinases (CDKs) is also cell-cycle regulated, and the yeast CDK Cdc28 controls DNA resection, an early step of homologous recombination. In this work, Huertas et al. show that the target of Cdc28 in regulating DNA resection is Sae2, a protein with endonuclease activity that was first identified as being required for meiotic recombination. These results support models in which the commitment to DSB resection is highly regulated to ensure that the cell engages the most appropriate DNA repair pathway at the right time, thereby optimizing genome stability.

Date: 2008
References: Add references at CitEc
Citations: View citations in EconPapers (5)

Downloads: (external link)
https://www.nature.com/articles/nature07215 Abstract (text/html)
Access to the full text of the articles in this series is restricted.

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:nature:v:455:y:2008:i:7213:d:10.1038_nature07215

Ordering information: This journal article can be ordered from
https://www.nature.com/

DOI: 10.1038/nature07215

Access Statistics for this article

Nature is currently edited by Magdalena Skipper

More articles in Nature from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().