Eukaryotic initiation factor 6 is rate-limiting in translation, growth and transformation

Valentina Gandin, Annarita Miluzio, Anna Maria Barbieri, Anne Beugnet, Hiroaki Kiyokawa, Pier Carlo Marchisio and Stefano Biffo ()
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Valentina Gandin: Molecular Histology and Cell Growth Laboratory, San Raffaele Science Institute, Via Olgettina 58, 20132 Milan, Italy
Annarita Miluzio: Molecular Histology and Cell Growth Laboratory, San Raffaele Science Institute, Via Olgettina 58, 20132 Milan, Italy
Anna Maria Barbieri: Molecular Histology and Cell Growth Laboratory, San Raffaele Science Institute, Via Olgettina 58, 20132 Milan, Italy
Anne Beugnet: Molecular Histology and Cell Growth Laboratory, San Raffaele Science Institute, Via Olgettina 58, 20132 Milan, Italy
Hiroaki Kiyokawa: Northwestern University, Feinberg School of Medicine, 303 East Avenue Chicago, Chicago, Illinois 60611, USA
Pier Carlo Marchisio: Molecular Histology and Cell Growth Laboratory, San Raffaele Science Institute, Via Olgettina 58, 20132 Milan, Italy
Stefano Biffo: Molecular Histology and Cell Growth Laboratory, San Raffaele Science Institute, Via Olgettina 58, 20132 Milan, Italy

Nature, 2008, vol. 455, issue 7213, 684-688

Abstract: eIF6: transmitter to the 60S ribosome Translation initiation is influenced by input from extracellular stimuli. While two eukaryotic initiation factors (eIFs) are known to transduce external signals to the small (40S) ribosomal subunit, it was not known whether an eIF served a similar function for the large (60S) ribosomal subunit. In this study, Gandin et al. show that eIF6 communicates extracellular signals to the 60S subunit. Cells from an eIF6 heterozygous mouse show normal ribosome assembly but reduced translation, delayed cell cycle progression, and impaired transformation. This work suggests that eIF6 acts an initiation factor, in vivo, and may control growth and tumorigenesis.

Date: 2008
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DOI: 10.1038/nature07267

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