UNC-6/netrin and its receptor UNC-5 locally exclude presynaptic components from dendrites

Vivian Y. Poon, Matthew P. Klassen and Kang Shen ()
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Vivian Y. Poon: Neuroscience Program, Stanford University School of Medicine, 300 Pasteur Drive, California 94305, USA
Matthew P. Klassen: Neuroscience Program, Stanford University School of Medicine, 300 Pasteur Drive, California 94305, USA
Kang Shen: Neuroscience Program, Stanford University School of Medicine, 300 Pasteur Drive, California 94305, USA

Nature, 2008, vol. 455, issue 7213, 669-673

Abstract: Axon guidance: cue here Neurons are highly polarized cells with distinct functional compartments — the dendrites and axons — that gate information input and output, respectively. Strict segregation of specific proteins to one or the other compartment, a phenomenon called cell polarization, is thought to be controlled intrinsically. New work by Vivian Poon et al. shows that in nematodes, the extracellular molecule Unc6/Netrin is both required in the vicinity of dendrites to prevent mislocalization of axonal proteins there, and is sufficient to exclude synaptic proteins from axon terminals if artificially provided close to these. The results extend to another extracellular protein, Wnt, and suggest that axon guidance cues also control local exclusion of axon terminal components from dendrites.

Date: 2008
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DOI: 10.1038/nature07291

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