STING is an endoplasmic reticulum adaptor that facilitates innate immune signalling

Hiroki Ishikawa and Glen N. Barber ()
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Hiroki Ishikawa: University of Miami School of Medicine, Miami, Florida 33136, USA
Glen N. Barber: University of Miami School of Medicine, Miami, Florida 33136, USA

Nature, 2008, vol. 455, issue 7213, 674-678

Abstract: Interferon stung into action Hiroki Ishikawa and Glen Barber report the identification of a molecule, STING (STimulator of INterferon Genes), that recognizes DNA and RNA virus infections and activates the body's innate immune system by triggering interferon production. STING, a previously uncharacterized protein, was isolated in an expression screen for its ability to activate the interferon-β promoter. It is located mainly in the endoplasmic reticulum and promotes interferon production via activation of the IRF3 and NF-κB pathways. It also interacts with RIG-I protein, a pattern recognition receptor involved in RNA virus detection, and with the translocon adaptor Sec61β, implicating the translocon or (the translocation channel involved in translocation of nascent polypeptides into the interior (cisternal or luminal) space of the endoplasmic reticulum in innate immune signalling.

Date: 2008
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DOI: 10.1038/nature07317

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