Dual epithelial origin of vertebrate oral teeth

Vladimír Soukup, Hans-Henning Epperlein, Ivan Horácek and Robert Cerny ()
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Vladimír Soukup: Charles University in Prague, Vinicna 7, 128 44 Prague, Czech Republic
Hans-Henning Epperlein: TU Dresden, Fetscherstrasse 74, 01307 Dresden, Germany
Ivan Horácek: Charles University in Prague, Vinicna 7, 128 44 Prague, Czech Republic
Robert Cerny: Charles University in Prague, Vinicna 7, 128 44 Prague, Czech Republic

Nature, 2008, vol. 455, issue 7214, 795-798

Abstract: The evolution of teeth: word of mouth The classical view of the evolution of vertebrate teeth is the 'outside-in' model, in which the oral cavity and oral teeth arise from the ectoderm by invagination. A study of transgenic axolotls (a type of salamander) now suggests that the picture is more complicated than that. Fate mapping of cells in the embryo reveals that oral teeth are derived from both ectoderm and endoderm: some even have a mixed ecto/endodermal origin. This implies a dominant role for neural crest mesenchyme over epithelia in tooth formation. The evolutionary implication is that the tooth-forming capacity of neural crest cells was the essential factor for teeth evolution, regardless of the 'outside-in' and 'inside-out' manoeuvres of the epithelium.

Date: 2008
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DOI: 10.1038/nature07304

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