The genome of the simian and human malaria parasite Plasmodium knowlesi

A. Pain (), U. Böhme, A. E. Berry, K. Mungall, R. D. Finn, A. P. Jackson, T. Mourier, J. Mistry, E. M. Pasini, M. A. Aslett, S. Balasubrammaniam, K. Borgwardt, K. Brooks, C. Carret, T. J. Carver, I. Cherevach, T. Chillingworth, T. G. Clark, M. R. Galinski, N. Hall, D. Harper, D. Harris, H. Hauser, A. Ivens, C. S. Janssen, T. Keane, N. Larke, S. Lapp, M. Marti, S. Moule, I. M. Meyer, D. Ormond, N. Peters, M. Sanders, S. Sanders, T. J. Sargeant, M. Simmonds, F. Smith, R. Squares, S. Thurston, A. R. Tivey, D. Walker, B. White, E. Zuiderwijk, C. Churcher, M. A. Quail, A. F. Cowman, C. M. R. Turner, M. A. Rajandream, C. H. M. Kocken, A. W. Thomas, C. I. Newbold, B. G. Barrell and M. Berriman
Additional contact information
A. Pain: Wellcome Trust Sanger Institute, Genome Campus, Hinxton, Cambridgeshire CB10 1SA, UK
U. Böhme: Wellcome Trust Sanger Institute, Genome Campus, Hinxton, Cambridgeshire CB10 1SA, UK
A. E. Berry: Wellcome Trust Sanger Institute, Genome Campus, Hinxton, Cambridgeshire CB10 1SA, UK
K. Mungall: Wellcome Trust Sanger Institute, Genome Campus, Hinxton, Cambridgeshire CB10 1SA, UK
R. D. Finn: Wellcome Trust Sanger Institute, Genome Campus, Hinxton, Cambridgeshire CB10 1SA, UK
A. P. Jackson: Wellcome Trust Sanger Institute, Genome Campus, Hinxton, Cambridgeshire CB10 1SA, UK
T. Mourier: Ancient DNA and Evolution Group, University of Copenhagen
J. Mistry: Wellcome Trust Sanger Institute, Genome Campus, Hinxton, Cambridgeshire CB10 1SA, UK
E. M. Pasini: Biomedical Primate Research Centre, PO Box 3306, 2280 GH, Rijswijk, The Netherlands
M. A. Aslett: Wellcome Trust Sanger Institute, Genome Campus, Hinxton, Cambridgeshire CB10 1SA, UK
S. Balasubrammaniam: Wellcome Trust Sanger Institute, Genome Campus, Hinxton, Cambridgeshire CB10 1SA, UK
K. Borgwardt: Machine Learning Group, University of Cambridge, Trumpington Street, Cambridge CB2 1PZ, UK
K. Brooks: Wellcome Trust Sanger Institute, Genome Campus, Hinxton, Cambridgeshire CB10 1SA, UK
C. Carret: Wellcome Trust Sanger Institute, Genome Campus, Hinxton, Cambridgeshire CB10 1SA, UK
T. J. Carver: Wellcome Trust Sanger Institute, Genome Campus, Hinxton, Cambridgeshire CB10 1SA, UK
I. Cherevach: Wellcome Trust Sanger Institute, Genome Campus, Hinxton, Cambridgeshire CB10 1SA, UK
T. Chillingworth: Wellcome Trust Sanger Institute, Genome Campus, Hinxton, Cambridgeshire CB10 1SA, UK
T. G. Clark: Wellcome Trust Sanger Institute, Genome Campus, Hinxton, Cambridgeshire CB10 1SA, UK
M. R. Galinski: Emory Vaccine Center, Yerkes National Primate Research Center, Emory University, 954 Gatewood Road, Atlanta, Georgia 30329, USA
N. Hall: School of Biological Sciences, University of Liverpool, PO Box 147, Liverpool L69 3BX, UK
D. Harper: Wellcome Trust Sanger Institute, Genome Campus, Hinxton, Cambridgeshire CB10 1SA, UK
D. Harris: Wellcome Trust Sanger Institute, Genome Campus, Hinxton, Cambridgeshire CB10 1SA, UK
H. Hauser: Wellcome Trust Sanger Institute, Genome Campus, Hinxton, Cambridgeshire CB10 1SA, UK
A. Ivens: Wellcome Trust Sanger Institute, Genome Campus, Hinxton, Cambridgeshire CB10 1SA, UK
C. S. Janssen: Institute of Biomedical and Life Sciences and Wellcome Centre for Molecular Parasitology, University of Glasgow, 120 University Place
T. Keane: Wellcome Trust Sanger Institute, Genome Campus, Hinxton, Cambridgeshire CB10 1SA, UK
N. Larke: Wellcome Trust Sanger Institute, Genome Campus, Hinxton, Cambridgeshire CB10 1SA, UK
S. Lapp: Emory Vaccine Center, Yerkes National Primate Research Center, Emory University, 954 Gatewood Road, Atlanta, Georgia 30329, USA
M. Marti: Harvard School of Public Health, 677 Huntington Avenue, Boston, Massachusetts 02115, USA
S. Moule: Wellcome Trust Sanger Institute, Genome Campus, Hinxton, Cambridgeshire CB10 1SA, UK
I. M. Meyer: 2366 Main Mall, British Columbia, Vancouver V6T 1Z4, Canada
D. Ormond: Wellcome Trust Sanger Institute, Genome Campus, Hinxton, Cambridgeshire CB10 1SA, UK
N. Peters: Wellcome Trust Sanger Institute, Genome Campus, Hinxton, Cambridgeshire CB10 1SA, UK
M. Sanders: Wellcome Trust Sanger Institute, Genome Campus, Hinxton, Cambridgeshire CB10 1SA, UK
S. Sanders: Wellcome Trust Sanger Institute, Genome Campus, Hinxton, Cambridgeshire CB10 1SA, UK
T. J. Sargeant: The Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria 3050, Australia
M. Simmonds: Wellcome Trust Sanger Institute, Genome Campus, Hinxton, Cambridgeshire CB10 1SA, UK
F. Smith: Wellcome Trust Sanger Institute, Genome Campus, Hinxton, Cambridgeshire CB10 1SA, UK
R. Squares: Wellcome Trust Sanger Institute, Genome Campus, Hinxton, Cambridgeshire CB10 1SA, UK
S. Thurston: Wellcome Trust Sanger Institute, Genome Campus, Hinxton, Cambridgeshire CB10 1SA, UK
A. R. Tivey: Wellcome Trust Sanger Institute, Genome Campus, Hinxton, Cambridgeshire CB10 1SA, UK
D. Walker: Wellcome Trust Sanger Institute, Genome Campus, Hinxton, Cambridgeshire CB10 1SA, UK
B. White: Wellcome Trust Sanger Institute, Genome Campus, Hinxton, Cambridgeshire CB10 1SA, UK
E. Zuiderwijk: Wellcome Trust Sanger Institute, Genome Campus, Hinxton, Cambridgeshire CB10 1SA, UK
C. Churcher: Wellcome Trust Sanger Institute, Genome Campus, Hinxton, Cambridgeshire CB10 1SA, UK
M. A. Quail: Wellcome Trust Sanger Institute, Genome Campus, Hinxton, Cambridgeshire CB10 1SA, UK
A. F. Cowman: The Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria 3050, Australia
C. M. R. Turner: Institute of Biomedical and Life Sciences and Wellcome Centre for Molecular Parasitology, University of Glasgow, 120 University Place
M. A. Rajandream: Wellcome Trust Sanger Institute, Genome Campus, Hinxton, Cambridgeshire CB10 1SA, UK
C. H. M. Kocken: Biomedical Primate Research Centre, PO Box 3306, 2280 GH, Rijswijk, The Netherlands
A. W. Thomas: Biomedical Primate Research Centre, PO Box 3306, 2280 GH, Rijswijk, The Netherlands
C. I. Newbold: Wellcome Trust Sanger Institute, Genome Campus, Hinxton, Cambridgeshire CB10 1SA, UK
B. G. Barrell: Wellcome Trust Sanger Institute, Genome Campus, Hinxton, Cambridgeshire CB10 1SA, UK
M. Berriman: Wellcome Trust Sanger Institute, Genome Campus, Hinxton, Cambridgeshire CB10 1SA, UK

Nature, 2008, vol. 455, issue 7214, 799-803

Abstract: MALARIA PARASITES: New Plasmodium sequences kick-start comparative genomics Four distinct Plasmodium species are known to regularly infect humans: Plasmodium falciparum, P. vivax, P. malariae and P. ovale. The genome sequence of P. falciparum, the cause of the most severe type of human malaria, was completed in 2002 at the same time as the mosquito vector, Anopheles gambiae. In this week's Nature, which focuses on the malaria parasite, two further malaria genome sequences are described. First that of P. vivax, which contributes significant numbers to malaria incidence in humans, though in contrast to P. falciparum, the resulting disease is usually not fatal. The genome of this rather neglected species is presented together with a comparative analysis with the genomes of other Plasmodium species. Second, we publish the genome sequence of Plasmodium knowlesi. For long regarded as a monkey malaria parasite, it is increasingly becoming recognized as the fifth human-infecting Plasmodium species. In particular, it is prevalent in South East Asia where it is often misdiagnosed as another human malaria parasite P. malariae. As a model organism P. knowlesi stands out: not only is it a primate system, useful for work on vaccines, but it can be cultured in vitro and subjected to efficient transfection and gene knockouts. In a Review Article, Elizabeth Winzeler considers the progress made towards using the genome sequence to understand basic malaria parasite biology, and in particular the work on developing rational therapeutic approaches to combat P. falciparum infections. See also the Editorial. For a comprehensive collection of resources visit Nature's past malaria specials: Malaria killer blow ; Outlook on malaria ; Malaria web focus ; Malaria Insight ; Nature Medicine focus on malaria ; Focus on malaria

Date: 2008
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DOI: 10.1038/nature07306

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