Comparative genomics of the neglected human malaria parasite Plasmodium vivax

Jane M. Carlton (), John H. Adams, Joana C. Silva, Shelby L. Bidwell, Hernan Lorenzi, Elisabet Caler, Jonathan Crabtree, Samuel V. Angiuoli, Emilio F. Merino, Paolo Amedeo, Qin Cheng, Richard M. R. Coulson, Brendan S. Crabb, Hernando A. del Portillo, Kobby Essien, Tamara V. Feldblyum, Carmen Fernandez-Becerra, Paul R. Gilson, Amy H. Gueye, Xiang Guo, Simon Kang’a, Taco W. A. Kooij, Michael Korsinczky, Esmeralda V.-S. Meyer, Vish Nene, Ian Paulsen, Owen White, Stuart A. Ralph, Qinghu Ren, Tobias J. Sargeant, Steven L. Salzberg, Christian J. Stoeckert, Steven A. Sullivan, Marcio M. Yamamoto, Stephen L. Hoffman, Jennifer R. Wortman, Malcolm J. Gardner, Mary R. Galinski, John W. Barnwell and Claire M. Fraser-Liggett
Additional contact information
Jane M. Carlton: The Institute for Genomic Research/J. Craig Venter Institute, 9704 Medical Research Drive, Rockville, Maryland 20850, USA
John H. Adams: College of Public Health, University of South Florida, 3720 Spectrum Boulevard, Suite 304, Tampa, Florida 33612, USA
Joana C. Silva: Department of Microbiology and Immunology,
Shelby L. Bidwell: The Institute for Genomic Research/J. Craig Venter Institute, 9704 Medical Research Drive, Rockville, Maryland 20850, USA
Hernan Lorenzi: The Institute for Genomic Research/J. Craig Venter Institute, 9704 Medical Research Drive, Rockville, Maryland 20850, USA
Elisabet Caler: The Institute for Genomic Research/J. Craig Venter Institute, 9704 Medical Research Drive, Rockville, Maryland 20850, USA
Jonathan Crabtree: The Institute for Genomic Research/J. Craig Venter Institute, 9704 Medical Research Drive, Rockville, Maryland 20850, USA
Samuel V. Angiuoli: Institute for Genome Sciences,
Emilio F. Merino: New York University Langone Medical Center, 341 East 25th Street, New York, New York 10010, USA
Paolo Amedeo: The Institute for Genomic Research/J. Craig Venter Institute, 9704 Medical Research Drive, Rockville, Maryland 20850, USA
Qin Cheng: Drug Resistance and Diagnostics, Australian Army Malaria Institute, Weary Dunlop Drive, Gallipoli Barracks, Enoggera, Queensland 4051, Australia
Richard M. R. Coulson: Microarray Group, European Bioinfomatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, UK
Brendan S. Crabb: The Walter & Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3050, Australia
Hernando A. del Portillo: Barcelona Centre for International Health Research, Hospital Clinic/IDIBAPS, Universitat de Barcelona Roselló 132, 4a planta, 08036 Barcelona, Spain
Kobby Essien: University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
Tamara V. Feldblyum: Institute for Genome Sciences,
Carmen Fernandez-Becerra: Barcelona Centre for International Health Research, Hospital Clinic/IDIBAPS, Universitat de Barcelona Roselló 132, 4a planta, 08036 Barcelona, Spain
Paul R. Gilson: The Walter & Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3050, Australia
Amy H. Gueye: Hood College, Frederick, Maryland 21701, USA
Xiang Guo: The Institute for Genomic Research/J. Craig Venter Institute, 9704 Medical Research Drive, Rockville, Maryland 20850, USA
Simon Kang’a: New York University Langone Medical Center, 341 East 25th Street, New York, New York 10010, USA
Taco W. A. Kooij: Heidelberg University School of Medicine, Im Neuenheimer Feld 324, Heidelberg 69120, Germany
Michael Korsinczky: Drug Resistance and Diagnostics, Australian Army Malaria Institute, Weary Dunlop Drive, Gallipoli Barracks, Enoggera, Queensland 4051, Australia
Esmeralda V.-S. Meyer: Emory Vaccine Center, Emory University, Atlanta, Georgia 30329, USA
Vish Nene: Department of Microbiology and Immunology,
Ian Paulsen: The Institute for Genomic Research/J. Craig Venter Institute, 9704 Medical Research Drive, Rockville, Maryland 20850, USA
Owen White: Institute for Genome Sciences,
Stuart A. Ralph: Bio21 Molecular Science and Biotechnology Institute, University of Melbourne
Qinghu Ren: The Institute for Genomic Research/J. Craig Venter Institute, 9704 Medical Research Drive, Rockville, Maryland 20850, USA
Tobias J. Sargeant: The Walter & Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3050, Australia
Steven L. Salzberg: Center for Bioinformatics and Computational Biology, University of Maryland, College Park, Maryland 20742, USA
Christian J. Stoeckert: University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
Steven A. Sullivan: New York University Langone Medical Center, 341 East 25th Street, New York, New York 10010, USA
Marcio M. Yamamoto: Instituto de Ciências Biomédicas, Universidade de São Paulo, Av. Lineu Prestes 1374, São Paulo, São Paulo 05508-900, Brazil
Stephen L. Hoffman: Sanaria Inc., 9800 Medical Center Drive, Rockville, Maryland 20850, USA
Jennifer R. Wortman: Institute for Genome Sciences,
Malcolm J. Gardner: The Institute for Genomic Research/J. Craig Venter Institute, 9704 Medical Research Drive, Rockville, Maryland 20850, USA
Mary R. Galinski: Institute for Molecular Bioscience, University of Queensland, Brisbane, Queensland 4072, Australia
John W. Barnwell: Malaria Branch, National Center for Zoonotic, Vector-borne and Enteric Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30341, USA
Claire M. Fraser-Liggett: Institute for Genome Sciences,

Nature, 2008, vol. 455, issue 7214, 757-763

Abstract: Abstract The human malaria parasite Plasmodium vivax is responsible for 25–40% of the ∼515 million annual cases of malaria worldwide. Although seldom fatal, the parasite elicits severe and incapacitating clinical symptoms and often causes relapses months after a primary infection has cleared. Despite its importance as a major human pathogen, P. vivax is little studied because it cannot be propagated continuously in the laboratory except in non-human primates. We sequenced the genome of P. vivax to shed light on its distinctive biological features, and as a means to drive development of new drugs and vaccines. Here we describe the synteny and isochore structure of P. vivax chromosomes, and show that the parasite resembles other malaria parasites in gene content and metabolic potential, but possesses novel gene families and potential alternative invasion pathways not recognized previously. Completion of the P. vivax genome provides the scientific community with a valuable resource that can be used to advance investigation into this neglected species.

Date: 2008
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DOI: 10.1038/nature07327

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