Promoter-driven splicing regulation in fission yeast

Alberto Moldón, Jordi Malapeira, Natalia Gabrielli, Madelaine Gogol, Blanca Gómez-Escoda, Tsvetomira Ivanova, Chris Seidel and José Ayté ()
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Alberto Moldón: Oxidative Stress and Cell Cycle Group, Universitat Pompeu Fabra, C/Doctor Aiguader 88, Barcelona 08003, Spain
Jordi Malapeira: Oxidative Stress and Cell Cycle Group, Universitat Pompeu Fabra, C/Doctor Aiguader 88, Barcelona 08003, Spain
Natalia Gabrielli: Oxidative Stress and Cell Cycle Group, Universitat Pompeu Fabra, C/Doctor Aiguader 88, Barcelona 08003, Spain
Madelaine Gogol: Stowers Institute, Kansas City, Missouri 64110, USA
Blanca Gómez-Escoda: Oxidative Stress and Cell Cycle Group, Universitat Pompeu Fabra, C/Doctor Aiguader 88, Barcelona 08003, Spain
Tsvetomira Ivanova: Oxidative Stress and Cell Cycle Group, Universitat Pompeu Fabra, C/Doctor Aiguader 88, Barcelona 08003, Spain
Chris Seidel: Stowers Institute, Kansas City, Missouri 64110, USA
José Ayté: Oxidative Stress and Cell Cycle Group, Universitat Pompeu Fabra, C/Doctor Aiguader 88, Barcelona 08003, Spain

Nature, 2008, vol. 455, issue 7215, 997-1000

Abstract: Cell cycle: what a difference a splice makes Genome-wide analyses in yeast have shown that the switch from mitosis to gamete-forming meiosis is associated with a dramatic change in gene expression profiles. One protein expressed only during meiosis is the cyclin Rem1, which enhances pre-meiotic intragenic recombination and ensures progression through meiosis. Moldón et al. now show that Rem1 expression in the fission yeast Saccharomyces pombe is controlled not only at the level of transcription, but also by splicing. In mitotic cells, binding of the Fkh2 transcription factor to the Rem1 promoter yields a transcript that retains its introns so that only a short protein is produced; this protein affects recombination levels. In meiotic cells, binding of a meiosis-specific transcription factor, Mei4, to the Rem1 promoter results in splicing of Rem1, and the active cyclin. Thus two transcription factors can differentially modify splicing of the same gene.

Date: 2008
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DOI: 10.1038/nature07325

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