Oncogenic mutations of ALK kinase in neuroblastoma

Yuyan Chen, Junko Takita, Young Lim Choi, Motohiro Kato, Miki Ohira, Masashi Sanada, Lili Wang, Manabu Soda, Akira Kikuchi, Takashi Igarashi, Akira Nakagawara, Yasuhide Hayashi (), Hiroyuki Mano and Seishi Ogawa ()
Additional contact information
Yuyan Chen: Department of Pediatrics,
Junko Takita: Department of Pediatrics,
Young Lim Choi: Jichi Medical University
Motohiro Kato: Department of Pediatrics,
Miki Ohira: Chiba Cancer Center Research Institute
Masashi Sanada: Cell Therapy and Transplantation Medicine,
Lili Wang: Cell Therapy and Transplantation Medicine,
Manabu Soda: Jichi Medical University
Akira Kikuchi: Saitama Children’s Medical Center
Takashi Igarashi: Department of Pediatrics,
Akira Nakagawara: Chiba Cancer Center Research Institute
Yasuhide Hayashi: Gunma Children’s Medical Center
Hiroyuki Mano: Jichi Medical University
Seishi Ogawa: Cell Therapy and Transplantation Medicine,

Nature, 2008, vol. 455, issue 7215, 971-974

Abstract: Neuroblastoma: a genetic link to ALK Neuroblastoma is the most common childhood cancer. There is a strong familial association and it was predicted over 30 years ago that there was a genetic element to the disease. Four groups now report the identification of mutations in the tyrosine kinase receptor ALK (anaplastic lymphoma kinase) in neuroblastoma patients. ALK acts as a neuroblastoma predisposition gene, and somatic point mutations occur in sporadic neuroblastoma cases. These mutations promote ALK's kinase activity and can transform cells and display tumorigenic activity in vivo. ALK inhibitors decrease neuroblastoma cell proliferation, so have potential as anticancer drugs.

Date: 2008
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DOI: 10.1038/nature07399

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