Copy-number variations associated with neuropsychiatric conditions

Edwin H. Cook and Stephen W. Scherer
Additional contact information
Edwin H. Cook: Institute for Juvenile Research, University of Illinois, 1747 West Roosevelt Road, Chicago, Illinois 60608, USA.
Stephen W. Scherer: The Centre for Applied Genomics, Hospital for Sick Children, 14th floor, Toronto Medical Discovery Tower/MaRS Discovery District

Nature, 2008, vol. 455, issue 7215, 919-923

Abstract: Abstract Neuropsychiatric conditions such as autism and schizophrenia have long been attributed to genetic alterations, but identifying the genes responsible has proved challenging. Microarray experiments have now revealed abundant copy-number variation — a type of variation in which stretches of DNA are duplicated, deleted and sometimes rearranged — in the human population. Genes affected by copy-number variation are good candidates for research into disease susceptibility. The complexity of neuropsychiatric genetics, however, dictates that assessment of the biomedical relevance of copy-number variants and the genes that they affect needs to be considered in an integrated context.

Date: 2008
References: Add references at CitEc
Citations: View citations in EconPapers (4)

Downloads: (external link)
https://www.nature.com/articles/nature07458 Abstract (text/html)
Access to the full text of the articles in this series is restricted.

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:nature:v:455:y:2008:i:7215:d:10.1038_nature07458

Ordering information: This journal article can be ordered from
https://www.nature.com/

DOI: 10.1038/nature07458

Access Statistics for this article

Nature is currently edited by Magdalena Skipper

More articles in Nature from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().