MicroRNAs to Nanog, Oct4 and Sox2 coding regions modulate embryonic stem cell differentiation

Yvonne Tay, Jinqiu Zhang, Andrew M. Thomson, Bing Lim and Isidore Rigoutsos ()
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Yvonne Tay: Stem Cell and Developmental Biology, Genome Institute of Singapore, Agency for Science Technology and Research (A*STAR), #08-01, Genome, 60 Biopolis Street, Singapore 138672, Singapore
Jinqiu Zhang: Stem Cell and Developmental Biology, Genome Institute of Singapore, Agency for Science Technology and Research (A*STAR), #08-01, Genome, 60 Biopolis Street, Singapore 138672, Singapore
Andrew M. Thomson: Stem Cell and Developmental Biology, Genome Institute of Singapore, Agency for Science Technology and Research (A*STAR), #08-01, Genome, 60 Biopolis Street, Singapore 138672, Singapore
Bing Lim: Stem Cell and Developmental Biology, Genome Institute of Singapore, Agency for Science Technology and Research (A*STAR), #08-01, Genome, 60 Biopolis Street, Singapore 138672, Singapore
Isidore Rigoutsos: Bioinformatics and Pattern Discovery Group, IBM Thomas J. Watson Research Center, Yorktown Heights, PO Box 218, New York 10598, USA

Nature, 2008, vol. 455, issue 7216, 1124-1128

Abstract: Molecular biology: in the midst of things Most miRNA target sequences that have been studied reside in the 3′ UTR, the part of the messenger RNA that is downstream of the coding region. In this work Rigoutsos and colleagues demonstrate that the coding regions of several genes encoding transcription factors involved in the maintenance of stem cell identity, such as Nanog, Oct4, and Sox2, have miRNA target sites. Three miRNAs that are upregulated when embryonic stem cells are induced to differentiate bind these sites in various combinations, and thereby confer specific phenotypes.

Date: 2008
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DOI: 10.1038/nature07299

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