Conjugated action of two species-specific invasion proteins for fetoplacental listeriosis

Olivier Disson, Solène Grayo, Eugénie Huillet, Georgios Nikitas, Francina Langa-Vives, Olivier Dussurget, Marie Ragon, Alban Le Monnier, Charles Babinet, Pascale Cossart and Marc Lecuit ()
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Olivier Disson: Institut Pasteur, Groupe Microorganismes et Barrières de l’Hôte, Unité des Interactions Bactéries-Cellules
Solène Grayo: Institut Pasteur, Groupe Microorganismes et Barrières de l’Hôte, Unité des Interactions Bactéries-Cellules
Eugénie Huillet: Institut Pasteur, Unité des Interactions Bactéries-Cellules
Georgios Nikitas: Institut Pasteur, Groupe Microorganismes et Barrières de l’Hôte, Unité des Interactions Bactéries-Cellules
Francina Langa-Vives: Institut Pasteur, Centre d’Ingénierie Génétique Murine
Olivier Dussurget: Institut Pasteur, Unité des Interactions Bactéries-Cellules
Marie Ragon: Institut Pasteur, Centre National de Référence des Listeria
Alban Le Monnier: Institut Pasteur, Centre National de Référence des Listeria
Charles Babinet: Institut Pasteur, Unité de Biologie du Développement
Pascale Cossart: Institut Pasteur, Unité des Interactions Bactéries-Cellules
Marc Lecuit: Institut Pasteur, Groupe Microorganismes et Barrières de l’Hôte, Unité des Interactions Bactéries-Cellules

Nature, 2008, vol. 455, issue 7216, 1114-1118

Abstract: Crossing the placental barrier Listeriosis and other microbial infections in pregnancy can affect the fetus as well as the mother, but little is known about how pathogens cross the placental barrier. Disson et al. investigated the process using two complementary animal models infected by Listeria monocytogenes. They show that two virulence factors or invasion proteins, InlA and InlB, are required for the transfer of pathogen to the placenta. Thus by blocking one or both of these pathways it may be possible to stop microbes passing into the fetus. Conversely, it may be possible to exploit these pathways to target therapeutic molecules across the same barrier.

Date: 2008
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DOI: 10.1038/nature07303

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