Paracrine Wingless signalling controls self-renewal of Drosophila intestinal stem cells

Guonan Lin, Na Xu and Rongwen Xi ()
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Guonan Lin: Graduate program, Peking Union Medical College and Chinese Academy of Medical Sciences
Na Xu: National Institute of Biological Sciences, No. 7 Science Park Road, Zhongguancun Life Science Park, Beijing 102206, China
Rongwen Xi: National Institute of Biological Sciences, No. 7 Science Park Road, Zhongguancun Life Science Park, Beijing 102206, China

Nature, 2008, vol. 455, issue 7216, 1119-1123

Abstract: Intestinal stem cells Multipotent intestine stem cells (ISCs) are present in the Drosophila midgut, and Notch pathway activity promotes downstream lineage differentiation to produce either enterocytes or enteroendocrine cells. How homeostasis of this process is regulated is unknown. Now Guonan Lin, Na Xu and Rongwen Xi show that the canonical Wnt signalling pathway controls ISC self-renewal. They also show that Notch acts downstream of the Wnt pathway and a hierarchy of Wg-Notch signalling pathway controls the balance between self-renewal and differentiation of ISCs. Interestingly, the mechanisms regulating ISCs from Drosophila to mammals appear to be conserved.

Date: 2008
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DOI: 10.1038/nature07329

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