Protein-folding location can regulate manganese-binding versus copper- or zinc-binding

Steve Tottey, Kevin J. Waldron, Susan J. Firbank, Brian Reale, Conrad Bessant, Katsuko Sato, Timothy R. Cheek, Joe Gray, Mark J. Banfield, Christopher Dennison and Nigel J. Robinson ()
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Steve Tottey: Cell and Molecular Biosciences, Medical School, Newcastle University
Kevin J. Waldron: Cell and Molecular Biosciences, Medical School, Newcastle University
Susan J. Firbank: Cell and Molecular Biosciences, Medical School, Newcastle University
Brian Reale: Cell and Molecular Biosciences, Medical School, Newcastle University
Conrad Bessant: Cranfield Bioinformatics Group, Cranfield University, Bedfordshire, MK43 0AL, UK
Katsuko Sato: Cell and Molecular Biosciences, Medical School, Newcastle University
Timothy R. Cheek: Cell and Molecular Biosciences, Medical School, Newcastle University
Joe Gray: Cell and Molecular Biosciences, Medical School, Newcastle University
Mark J. Banfield: Cell and Molecular Biosciences, Medical School, Newcastle University
Christopher Dennison: Cell and Molecular Biosciences, Medical School, Newcastle University
Nigel J. Robinson: Cell and Molecular Biosciences, Medical School, Newcastle University

Nature, 2008, vol. 455, issue 7216, 1138-1142

Abstract: Protein folding: choosing the right metal Metal ions are needed by at least a quarter of proteins — although metallochaperones insert the 'correct' metal ion into some metal-containing proteins, metallochaperones have not been found for a large proportion of metalloproteins. It seems likely that some metalloproteins acquire their metal ions directly from cellular pools — but some metal ions form more stable metal ion/protein-complexes than others, so it is not clear what cellular mechanisms enables a nascent protein to incorporate the correct metal ion. In this manuscript, the authors identified the most abundant Cu2+ and Mn2+ containing proteins in the periplasm of a cyanobacterium and determined that the cellular compartment in which each of those proteins fold is responsible for the insertion of the correct metal ion into the metalloprotein.

Date: 2008
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DOI: 10.1038/nature07340

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