MicroRNA-10b and breast cancer metastasis

Harriet E. Gee (), Carme Camps, Francesca M. Buffa (), Stefano Colella, Helen Sheldon (), Jonathan M. Gleadle, Jiannis Ragoussis and Adrian L. Harris ()
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Harriet E. Gee: Cancer Research UK Molecular Oncology Laboratories, Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital
Carme Camps: Genomics Group, Wellcome Trust Centre for Human Genetics, The Henry Wellcome Building for Genomic Medicine, University of Oxford
Francesca M. Buffa: Cancer Research UK Molecular Oncology Laboratories, Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital
Stefano Colella: Genomics Group, Wellcome Trust Centre for Human Genetics, The Henry Wellcome Building for Genomic Medicine, University of Oxford
Helen Sheldon: Cancer Research UK Molecular Oncology Laboratories, Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital
Jonathan M. Gleadle: Flinders Medical Centre, Bedford Park, South Australia, 5042, Australia
Jiannis Ragoussis: Genomics Group, Wellcome Trust Centre for Human Genetics, The Henry Wellcome Building for Genomic Medicine, University of Oxford
Adrian L. Harris: Cancer Research UK Molecular Oncology Laboratories, Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital

Nature, 2008, vol. 455, issue 7216, E8-E9

Abstract: Abstract Arising from: L. Ma, J. Teruya-Feldstein & R. A. Weinberg Nature 449, 682–688 (2007)10.1038/nature06174 ; Ma et al. reply MicroRNAs regulate messenger RNA expression but are frequently dysregulated in tumours. Ma et al.1 report that overexpression of microRNA-10b (miR-10b) initiates invasion and metastasis in models of breast cancer and that its expression in primary breast carcinomas correlates with clinical progression. We tested this in patients with primary breast cancer, of whom 92 had nodal metastases at diagnosis and 127 were node-negative. We found no significant association between miR-10b levels and metastasis or prognosis. Although we concede that miR-10b may have a biological effect in a few cells at the growing edge of a tumour, we believe that it is unlikely to correlate in whole tumour samples with clinical progression.

Date: 2008
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DOI: 10.1038/nature07362

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