p53 and Pten control neural and glioma stem/progenitor cell renewal and differentiation

Hongwu Zheng, Haoqiang Ying, Haiyan Yan, Alec C. Kimmelman, David J. Hiller, An-Jou Chen, Samuel R. Perry, Giovanni Tonon, Gerald C. Chu, Zhihu Ding, Jayne M. Stommel, Katherine L. Dunn, Ruprecht Wiedemeyer, Mingjian J. You, Cameron Brennan, Y. Alan Wang, Keith L. Ligon, Wing H. Wong, Lynda Chin and Ronald A. DePinho ()
Additional contact information
Hongwu Zheng: Department of Medical Oncology,
Haoqiang Ying: Department of Medical Oncology,
Haiyan Yan: Department of Medical Oncology,
Alec C. Kimmelman: Department of Medical Oncology,
David J. Hiller: Stanford University, Stanford, California 94305, USA
An-Jou Chen: Department of Medical Oncology,
Samuel R. Perry: Department of Medical Oncology,
Giovanni Tonon: Department of Medical Oncology,
Gerald C. Chu: Department of Medical Oncology,
Zhihu Ding: Department of Medical Oncology,
Jayne M. Stommel: Department of Medical Oncology,
Katherine L. Dunn: Department of Medical Oncology,
Ruprecht Wiedemeyer: Department of Medical Oncology,
Mingjian J. You: Department of Medical Oncology,
Cameron Brennan: Memorial Sloan-Kettering Cancer Center, New York, New York 10065, USA
Y. Alan Wang: Department of Medical Oncology,
Keith L. Ligon: Department of Medical Oncology,
Wing H. Wong: Stanford University, Stanford, California 94305, USA
Lynda Chin: Department of Medical Oncology,
Ronald A. DePinho: Department of Medical Oncology,

Nature, 2008, vol. 455, issue 7216, 1129-1133

Abstract: Glioblastoma: large-scale genomics and a lab model The Cancer Genome Atlas, a large-scale genomics project to catalogue cancer-linked mutations, is starting to produce results. Glioblastoma, the most common brain cancer, was the first target for the project and the initial results, published AOP on 4 September, are now in print. Genes newly implicated in glioblastoma include tumour suppressors (NF1, RB1, ATM and APC) and several tyrosine kinase genes. Glioblastoma is extremely resistant to therapy, hence the potential importance of the development of a possible model system. Zheng et al. report that mice lacking the tumour suppressors p53 and Pten develop tumours resembling human glioblastomas, associated with increased Myc protein levels. As well as offering a potential system for testing therapeutics, this points to c-Myc as a possible drug target.

Date: 2008
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DOI: 10.1038/nature07443

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