Concurrent nucleation of 16S folding and induced fit in 30S ribosome assembly

Tadepalli Adilakshmi, Deepti L. Bellur and Sarah A. Woodson ()
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Tadepalli Adilakshmi: Present address: Weis Center for Research, Geisinger Medical Center, 100 North Academy Avenue, Danville, Pennsylvania 17822, USA (T.A.); Department of Molecular Genetics and Cell Biology, The University of Chicago, 920 East 58th Street, Chicago, Illinois 60637, USA (D.L.B).
Deepti L. Bellur: Present address: Weis Center for Research, Geisinger Medical Center, 100 North Academy Avenue, Danville, Pennsylvania 17822, USA (T.A.); Department of Molecular Genetics and Cell Biology, The University of Chicago, 920 East 58th Street, Chicago, Illinois 60637, USA (D.L.B).
Sarah A. Woodson: and

Nature, 2008, vol. 455, issue 7217, 1268-1272

Abstract: Induced fit in ribosome assembly Ribosome assembly has to be fast and efficient, given the demand for protein synthesis in rapidly dividing cells. In this work, Woodson and colleagues use a footprinting method with high time resolution to map how the structure of the small subunit's 16S rRNA changes as proteins assemble on it. While several regions of the rRNA adopt secondary structure rapidly, both the region of the decoding site and interactions between the 5′, central and 3′ regions require much more time to form, suggesting that an induced fit reaction is occurring.

Date: 2008
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DOI: 10.1038/nature07298

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