Structural insights into amino acid binding and gene control by a lysine riboswitch

Alexander Serganov (), Lili Huang and Dinshaw J. Patel ()
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Alexander Serganov: Structural Biology Program, Memorial Sloan-Kettering Cancer Center, New York, New York 10065, USA
Lili Huang: Structural Biology Program, Memorial Sloan-Kettering Cancer Center, New York, New York 10065, USA
Dinshaw J. Patel: Structural Biology Program, Memorial Sloan-Kettering Cancer Center, New York, New York 10065, USA

Nature, 2008, vol. 455, issue 7217, 1263-1267

Abstract: Riboswitch mechanisms Riboswitches are structured RNAs that can bind a ligand such as a metabolite or nucleobase. Binding of the ligand affects the function of the RNA, so that they are often found in regulatory loops. In this work Patel and colleagues report the structure of a riboswitch that binds the amino acid lysine. The scaffold of the riboswitch is preassembled, but conformational changes occur upon binding lysine that direct further changes in the RNA downstream of the switch. Structures of the riboswitch with lysine analogues, including an antibiotic, provide some insight the development of resistance.

Date: 2008
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DOI: 10.1038/nature07326

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