GILT is a critical host factor for Listeria monocytogenes infection

Reshma Singh, Amanda Jamieson and Peter Cresswell ()
Additional contact information
Reshma Singh: Department of Immunobiology,
Amanda Jamieson: Department of Immunobiology,
Peter Cresswell: Department of Immunobiology,

Nature, 2008, vol. 455, issue 7217, 1244-1247

Abstract: Listeriosis: host's GILT aids infection The bacterium Listeria monocytogenes is a food-borne pathogen that can cause severe illness in humans and animals. Now the enzyme GILT (interferon-γ-inducible lysosomal thiol reductase) has been identified as a critical host factor for infection by L. monocytogenes. Once in the body Listeria produces a pore-forming toxin, listeriolysin O (LLO), that releases phagocytosed bacteria into the cytosol of macrophages where they can replicate. LLO needs to be reduced before it becomes active, and it is the host's GILT enzyme that mediates this reduction. Mice lacking GILT are resistant to Listeria. This work offers a new potential therapeutic target for a disease where antibiotic resistance is of growing concern.

Date: 2008
References: Add references at CitEc
Citations:

Downloads: (external link)
https://www.nature.com/articles/nature07344 Abstract (text/html)
Access to the full text of the articles in this series is restricted.

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:nature:v:455:y:2008:i:7217:d:10.1038_nature07344

Ordering information: This journal article can be ordered from
https://www.nature.com/

DOI: 10.1038/nature07344

Access Statistics for this article

Nature is currently edited by Magdalena Skipper

More articles in Nature from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().