Histone H2A.Z and DNA methylation are mutually antagonistic chromatin marks

Daniel Zilberman (), Devin Coleman-Derr, Tracy Ballinger and Steven Henikoff ()
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Daniel Zilberman: University of California, 211 Koshland Hall, Berkeley, California 94720, USA
Devin Coleman-Derr: University of California, 211 Koshland Hall, Berkeley, California 94720, USA
Tracy Ballinger: Fred Hutchinson Cancer Research Center, and,
Steven Henikoff: Fred Hutchinson Cancer Research Center, and,

Nature, 2008, vol. 456, issue 7218, 125-129

Abstract: Plant chromatin: DNA methylation versus histone H2A.Z Although DNA methylation has been actively studied for several decades, the mechanism by which it causes gene silencing remains largely unknown. In contrast to DNA methylation, the histone variant H2A.Z promotes transcriptional competence in plants, animals and fungi. This paper reports the finding that regions of DNA methylation in the Arabidopsis thaliana genome are deficient in H2A.Z. DNA methylation appears to repress transcription by exclusion of H2A.Z. This suggets a novel relationship between a covalent modification of DNA and a core nucleosome component with an important role in organizing eukaryotic chromatin.

Date: 2008
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DOI: 10.1038/nature07324

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