The CRAC channel consists of a tetramer formed by Stim-induced dimerization of Orai dimers

Aubin Penna, Angelo Demuro, Andriy V. Yeromin, Shenyuan L. Zhang, Olga Safrina, Ian Parker and Michael D. Cahalan ()
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Aubin Penna: Department of Physiology and Biophysics,
Angelo Demuro: and
Andriy V. Yeromin: Department of Physiology and Biophysics,
Shenyuan L. Zhang: Department of Physiology and Biophysics,
Olga Safrina: Department of Physiology and Biophysics,
Ian Parker: Department of Physiology and Biophysics,
Michael D. Cahalan: Department of Physiology and Biophysics,

Nature, 2008, vol. 456, issue 7218, 116-120

Abstract: CRAC channels: dimerization the key? The mechanism underlying activation of Ca2+ release-activated Ca2+ channels, in response to depletion of intracellular Ca2+ stores, has generated much interest. Recently, it was shown that Stim forms the relay between the Ca2+ store and the plasma membrane, where it activates the ion-channel forming protein Orai. Here, Penna et al. show that Orai is a dimer at rest and a tetramer when activated by Stim, raising the interesting possibility that dimerization is the trigger for channel activation.

Date: 2008
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DOI: 10.1038/nature07338

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