Stepwise chromatin remodelling by a cascade of transcription initiation of non-coding RNAs

Kouji Hirota (), Tomoichiro Miyoshi, Kazuto Kugou, Charles S. Hoffman, Takehiko Shibata and Kunihiro Ohta ()
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Kouji Hirota: Cellular & Molecular Biology Laboratory, RIKEN Advanced Science Institute, Wako-shi, Saitama 351-0198, Japan
Tomoichiro Miyoshi: Graduate School of Arts and Sciences, The University of Tokyo, Komaba 3-8-1, Meguro-ku, Tokyo 153-8902, Japan
Kazuto Kugou: Cellular & Molecular Biology Laboratory, RIKEN Advanced Science Institute, Wako-shi, Saitama 351-0198, Japan
Charles S. Hoffman: Boston College, Chestnut Hill, Massachusetts 02467, USA
Takehiko Shibata: Cellular & Molecular Biology Laboratory, RIKEN Advanced Science Institute, Wako-shi, Saitama 351-0198, Japan
Kunihiro Ohta: Cellular & Molecular Biology Laboratory, RIKEN Advanced Science Institute, Wako-shi, Saitama 351-0198, Japan

Nature, 2008, vol. 456, issue 7218, 130-134

Abstract: Non-coding RNAs active in chromatin remodellng Non-coding RNAs are abundant, yet their function is still largely unknown. Here, non-coding RNA transcripts are detected at the fission yeast fbp1+ locus, upstream of the normal transcription initiation site. Transcription of these non-coding RNAs through the promoter region of fbp1+ is required for chromatin remodelling and robust activation of fbp1+ during glucose starvation. This study provides evidence for a role for ncRNAs in RNAPII transcription during the formation of transcriptionally-active chromatin, hinting at a potentially important biological role for ncRNAs observed in higher eukaryotes.

Date: 2008
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DOI: 10.1038/nature07348

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