A fasting inducible switch modulates gluconeogenesis via activator/coactivator exchange

Yi Liu, Renaud Dentin, Danica Chen, Susan Hedrick, Kim Ravnskjaer, Simon Schenk, Jill Milne, David J. Meyers, Phil Cole, John Yates, Jerrold Olefsky, Leonard Guarente and Marc Montminy ()
Additional contact information
Yi Liu: The Salk Institute for Biological Studies, 10010 North Torrey Pines Rd, La Jolla, California 92037, USA
Renaud Dentin: The Salk Institute for Biological Studies, 10010 North Torrey Pines Rd, La Jolla, California 92037, USA
Danica Chen: Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
Susan Hedrick: The Salk Institute for Biological Studies, 10010 North Torrey Pines Rd, La Jolla, California 92037, USA
Kim Ravnskjaer: The Salk Institute for Biological Studies, 10010 North Torrey Pines Rd, La Jolla, California 92037, USA
Simon Schenk: University of California, San Diego, La Jolla, California 92093, USA
Jill Milne: Sirtris Pharmaceuticals Inc., 200 Technology Square, Cambridge, Massachusetts 02139, USA
David J. Meyers: Johns Hopkins University School of Medicine, 725 North Wolfe Street, 316 Hunterian Building, Baltimore, Maryland 21205, USA
Phil Cole: Johns Hopkins University School of Medicine, 725 North Wolfe Street, 316 Hunterian Building, Baltimore, Maryland 21205, USA
John Yates: The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA
Jerrold Olefsky: University of California, San Diego, La Jolla, California 92093, USA
Leonard Guarente: Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
Marc Montminy: The Salk Institute for Biological Studies, 10010 North Torrey Pines Rd, La Jolla, California 92037, USA

Nature, 2008, vol. 456, issue 7219, 269-273

Abstract: Maintaining energy balance in fasting A fasting-inducible switch, consisting of the histone acetyl transferase p300 and the nutrient-sensing NAD+-dependent deacetylase SIRT1, is shown to maintain energy balance during fasting by promoting the sequential induction of the transcription factors TORC2 and FOXO1. This illustrates how the exchange of two gluconeogenic regulators during fasting maintains energy balance.

Date: 2008
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DOI: 10.1038/nature07349

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