Oligopotent stem cells are distributed throughout the mammalian ocular surface

François Majo, Ariane Rochat, Michael Nicolas, Georges Abou Jaoudé and Yann Barrandon ()
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François Majo: Laboratory of Stem Cell Dynamics,
Ariane Rochat: Laboratory of Stem Cell Dynamics,
Michael Nicolas: Laboratory of Stem Cell Dynamics,
Georges Abou Jaoudé: Laboratory of Informatics and Visualization, Ecole Polytechnique Fédérale de Lausanne (EPFL), 1015 Lausanne CH, Switzerland
Yann Barrandon: Laboratory of Stem Cell Dynamics,

Nature, 2008, vol. 456, issue 7219, 250-254

Abstract: Corneal stem cell niches It has been believed based on BrdU studies that the limbus is the niche for the stem cells responsible for the long-term renewal of the cornea. Majo et al. show instead that the renewal of the corneal epithelium is not different from other squamous epithelia, and is self-maintained without limbal contribution. The authors also show that the entire ocular surface of the pig, including the central cornea, contains stem cells that are oligopotent and can generate individual colonies of corneal and conjunctival cells. They propose that the limbus is not the sole niche for corneal stem cells.

Date: 2008
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DOI: 10.1038/nature07406

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