A key role for autophagy and the autophagy gene Atg16l1 in mouse and human intestinal Paneth cells

Ken Cadwell, John Y. Liu, Sarah L. Brown, Hiroyuki Miyoshi, Joy Loh, Jochen K. Lennerz, Chieko Kishi, Wumesh Kc, Javier A. Carrero, Steven Hunt, Christian D. Stone, Elizabeth M. Brunt, Ramnik J. Xavier, Barry P. Sleckman, Ellen Li, Noboru Mizushima, Thaddeus S. Stappenbeck () and Herbert W. Virgin Iv ()
Additional contact information
Ken Cadwell: Department of Pathology and Immunology,
John Y. Liu: Department of Pathology and Immunology,
Sarah L. Brown: Department of Pathology and Immunology,
Hiroyuki Miyoshi: Department of Pathology and Immunology,
Joy Loh: Department of Pathology and Immunology,
Jochen K. Lennerz: Department of Pathology and Immunology,
Chieko Kishi: Tokyo Medical and Dental University Graduate School and Faculty of Medicine
Wumesh Kc: Department of Pathology and Immunology,
Javier A. Carrero: Department of Pathology and Immunology,
Steven Hunt: Department of Surgery,
Christian D. Stone: Department of Medicine,
Elizabeth M. Brunt: Department of Pathology and Immunology,
Ramnik J. Xavier: Center for Computational and Integrative Biology and Gastrointestinal Unit, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
Barry P. Sleckman: Department of Pathology and Immunology,
Ellen Li: Department of Medicine,
Noboru Mizushima: Tokyo Medical and Dental University Graduate School and Faculty of Medicine
Thaddeus S. Stappenbeck: Department of Pathology and Immunology,
Herbert W. Virgin Iv: Department of Pathology and Immunology,

Nature, 2008, vol. 456, issue 7219, 259-263

Abstract: Inflammatory bowel disease Crohn's disease, a chronic inflammation of the gut, has been linked to over thirty gene loci. Two papers in this issue focus a recent addition to that list, ATG16L1 (Atg16-like 1). Atg16 protein itself was first identified in yeast as an essential gene for the process of autophagy, a system that clears away unwanted cellular components and is involved in the pathogenesis of microbial infection, neurodegeneration and tumorigenesis. Cadwell et al. report a unique role for Atg16L1 in Paneth cells, a type of epithelial cell that secretes granules containing antimicrobial peptides into the intestines. Saitoh et al. show that ATG16L1 plays a role in the inflammatory response in isolated macrophages and in the mouse intestine, as an essential component of the autophagic machinery. This work implicates Atg16L1 in the control of inflammatory immune response and the maintenance of intestinal barrier, both of which are important for the prevention of inflammatory bowel disease.

Date: 2008
References: Add references at CitEc
Citations: View citations in EconPapers (3)

Downloads: (external link)
https://www.nature.com/articles/nature07416 Abstract (text/html)
Access to the full text of the articles in this series is restricted.

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:nature:v:456:y:2008:i:7219:d:10.1038_nature07416

Ordering information: This journal article can be ordered from
https://www.nature.com/

DOI: 10.1038/nature07416

Access Statistics for this article

Nature is currently edited by Magdalena Skipper

More articles in Nature from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().