Generation of pluripotent stem cells from adult human testis

Sabine Conrad, Markus Renninger, Jörg Hennenlotter, Tina Wiesner, Lothar Just, Michael Bonin, Wilhelm Aicher, Hans-Jörg Bühring, Ulrich Mattheus, Andreas Mack, Hans-Joachim Wagner, Stephen Minger, Matthias Matzkies, Michael Reppel, Jürgen Hescheler, Karl-Dietrich Sievert, Arnulf Stenzl and Thomas Skutella ()
Additional contact information
Sabine Conrad: Institute of Anatomy
Markus Renninger: University Clinic Tübingen, Hoppe-Seyler-Straße 3, Tübingen 72076, Germany
Jörg Hennenlotter: University Clinic Tübingen, Hoppe-Seyler-Straße 3, Tübingen 72076, Germany
Tina Wiesner: Institute of Anatomy
Lothar Just: Institute of Anatomy
Michael Bonin: Institute of Anthropology and Human Genetics, Microarray Facility, University Clinic, Calwerstraße 7, 72076 Tübingen, Germany
Wilhelm Aicher: ZMF Research Laboratories, University Clinic Tübingen, Waldhörnlestraße 22, 72072 Tübingen, Germany
Hans-Jörg Bühring: University Clinic Tübingen, Otfried-Müller-Straße 10, 72076 Tübingen, Germany
Ulrich Mattheus: Institute of Anatomy, Österbergstraße 3, 72074 Tübingen, Germany
Andreas Mack: Institute of Anatomy, Österbergstraße 3, 72074 Tübingen, Germany
Hans-Joachim Wagner: Institute of Anatomy, Österbergstraße 3, 72074 Tübingen, Germany
Stephen Minger: Stem Cell Biology Laboratory, Wolfson Centre for Age-Related Diseases, King's College London, King's College
Matthias Matzkies: Institute of Neurophysiology, University of Cologne, Robert-Koch-Straße 39, 50931 Cologne, Germany
Michael Reppel: Institute of Neurophysiology, University of Cologne, Robert-Koch-Straße 39, 50931 Cologne, Germany
Jürgen Hescheler: Institute of Neurophysiology, University of Cologne, Robert-Koch-Straße 39, 50931 Cologne, Germany
Karl-Dietrich Sievert: University Clinic Tübingen, Hoppe-Seyler-Straße 3, Tübingen 72076, Germany
Arnulf Stenzl: University Clinic Tübingen, Hoppe-Seyler-Straße 3, Tübingen 72076, Germany
Thomas Skutella: Institute of Anatomy

Nature, 2008, vol. 456, issue 7220, 344-349

Abstract: Abstract Human primordial germ cells and mouse neonatal and adult germline stem cells are pluripotent and show similar properties to embryonic stem cells. Here we report the successful establishment of human adult germline stem cells derived from spermatogonial cells of adult human testis. Cellular and molecular characterization of these cells revealed many similarities to human embryonic stem cells, and the germline stem cells produced teratomas after transplantation into immunodeficient mice. The human adult germline stem cells differentiated into various types of somatic cells of all three germ layers when grown under conditions used to induce the differentiation of human embryonic stem cells. We conclude that the generation of human adult germline stem cells from testicular biopsies may provide simple and non-controversial access to individual cell-based therapy without the ethical and immunological problems associated with human embryonic stem cells.

Date: 2008
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DOI: 10.1038/nature07404

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