Sequencing the nuclear genome of the extinct woolly mammoth

Webb Miller (), Daniela I. Drautz, Aakrosh Ratan, Barbara Pusey, Ji Qi, Arthur M. Lesk, Lynn P. Tomsho, Michael D. Packard, Fangqing Zhao, Andrei Sher, Alexei Tikhonov, Brian Raney, Nick Patterson, Kerstin Lindblad-Toh, Eric S. Lander, James R. Knight, Gerard P. Irzyk, Karin M. Fredrikson, Timothy T. Harkins, Sharon Sheridan, Tom Pringle and Stephan C. Schuster ()
Additional contact information
Webb Miller: Pennsylvania State University, Center for Comparative Genomics and Bioinformatics, 310 Wartik Building, University Park, Pennsylvania 16802, USA
Daniela I. Drautz: Pennsylvania State University, Center for Comparative Genomics and Bioinformatics, 310 Wartik Building, University Park, Pennsylvania 16802, USA
Aakrosh Ratan: Pennsylvania State University, Center for Comparative Genomics and Bioinformatics, 310 Wartik Building, University Park, Pennsylvania 16802, USA
Barbara Pusey: Pennsylvania State University, Center for Comparative Genomics and Bioinformatics, 310 Wartik Building, University Park, Pennsylvania 16802, USA
Ji Qi: Pennsylvania State University, Center for Comparative Genomics and Bioinformatics, 310 Wartik Building, University Park, Pennsylvania 16802, USA
Arthur M. Lesk: Pennsylvania State University, Center for Comparative Genomics and Bioinformatics, 310 Wartik Building, University Park, Pennsylvania 16802, USA
Lynn P. Tomsho: Pennsylvania State University, Center for Comparative Genomics and Bioinformatics, 310 Wartik Building, University Park, Pennsylvania 16802, USA
Michael D. Packard: Pennsylvania State University, Center for Comparative Genomics and Bioinformatics, 310 Wartik Building, University Park, Pennsylvania 16802, USA
Fangqing Zhao: Pennsylvania State University, Center for Comparative Genomics and Bioinformatics, 310 Wartik Building, University Park, Pennsylvania 16802, USA
Andrei Sher: Severtsov Institute of Ecology and Evolution, Russian Academy of Sciences, 33 Leninsky Prospect, 119071 Moscow, Russia
Alexei Tikhonov: Zoological Institute, Russian Academy of Sciences, Universitetskaya Naberezhnaya 1
Brian Raney: Center for Biomolecular Science and Engineering, University of California, Santa Cruz, California 95064, USA
Nick Patterson: Broad Institute of MIT and Harvard, 7 Cambridge Center, Cambridge, Massachusetts 02142, USA
Kerstin Lindblad-Toh: Broad Institute of MIT and Harvard, 7 Cambridge Center, Cambridge, Massachusetts 02142, USA
Eric S. Lander: Broad Institute of MIT and Harvard, 7 Cambridge Center, Cambridge, Massachusetts 02142, USA
James R. Knight: 454 Life Sciences, 20 Commercial Street, Branford, Connecticut 06405, USA
Gerard P. Irzyk: 454 Life Sciences, 20 Commercial Street, Branford, Connecticut 06405, USA
Karin M. Fredrikson: Roche Diagnostics Corporation, 9115 Hague Road, Indianapolis, Indiana 46250-0414, USA
Timothy T. Harkins: Roche Diagnostics Corporation, 9115 Hague Road, Indianapolis, Indiana 46250-0414, USA
Sharon Sheridan: Roche Diagnostics Corporation, 9115 Hague Road, Indianapolis, Indiana 46250-0414, USA
Tom Pringle: Sperling Foundation, Eugene, Oregon 97405, USA
Stephan C. Schuster: Pennsylvania State University, Center for Comparative Genomics and Bioinformatics, 310 Wartik Building, University Park, Pennsylvania 16802, USA

Nature, 2008, vol. 456, issue 7220, 387-390

Abstract: Palaeogenes: mammoth task Ancient DNA isolated from fossils and tissue preserved in permafrost has long held a fascination. Though broken up into small scraps and all-but swamped by modern microbial DNA, its sequences have provided glimpses of extinct life forms. Now the same massively parallel synthetic DNA sequencing technologies that are bringing the personal genomics revolution have revolutionized the field of ancient DNA too. The first report of the sequencing of the nearly complete nuclear genome of an extinct animal — the woolly mammoth — appears in this issue. Comparison of the woolly mammoth genome with that of the African elephant show that unexpectedly, both genomes are likely to be at least 40% larger than those of the fully sequence placental mammals. The recent PNAS paper on the cloning of mice from bodies stored in a freezer for 16 years prompted news reports that the cloning of mammoths was imminent. How likely is that? Henry Nicholls asks the question and concludes that for now, it is still fantasy. But that is what cloning mammals was just 15 years ago. Watch this space, but be patient.

Date: 2008
References: Add references at CitEc
Citations: View citations in EconPapers (1)

Downloads: (external link)
https://www.nature.com/articles/nature07446 Abstract (text/html)
Access to the full text of the articles in this series is restricted.

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:nature:v:456:y:2008:i:7220:d:10.1038_nature07446

Ordering information: This journal article can be ordered from
https://www.nature.com/

DOI: 10.1038/nature07446

Access Statistics for this article

Nature is currently edited by Magdalena Skipper

More articles in Nature from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().