Self-renewal and expansion of single transplanted muscle stem cells

Alessandra Sacco, Regis Doyonnas, Peggy Kraft, Stefan Vitorovic and Helen M. Blau ()
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Alessandra Sacco: Baxter Laboratory in Genetic Pharmacology, Stem Cell Institute, Stanford University School of Medicine, Stanford, California 94305-5175, USA
Regis Doyonnas: Baxter Laboratory in Genetic Pharmacology, Stem Cell Institute, Stanford University School of Medicine, Stanford, California 94305-5175, USA
Peggy Kraft: Baxter Laboratory in Genetic Pharmacology, Stem Cell Institute, Stanford University School of Medicine, Stanford, California 94305-5175, USA
Stefan Vitorovic: Baxter Laboratory in Genetic Pharmacology, Stem Cell Institute, Stanford University School of Medicine, Stanford, California 94305-5175, USA
Helen M. Blau: Baxter Laboratory in Genetic Pharmacology, Stem Cell Institute, Stanford University School of Medicine, Stanford, California 94305-5175, USA

Nature, 2008, vol. 456, issue 7221, 502-506

Abstract: Robust muscle stem cells Muscle satellite cells are quiescent cells found in the spaces between a muscle fibre and its membranous sheath, where they respond to damage by forming progenitors that fuse with muscle fibres. There are reports that they can act as stem cells, but the mixed nature of satellite cell populations means that their 'stem-cell-ness' is difficult to prove. Sacco et al. have clarified matters by using clonal analysis to confirm that satellite cells are indeed stem cells, capable of self renewal. They transplant a single luciferase-expressing satellite cell into the muscle of mice, and show that it is capable of extensive proliferation, contributes to muscle fibres, and can be re-transplanted.

Date: 2008
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DOI: 10.1038/nature07384

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