A fast, robust and tunable synthetic gene oscillator

Jesse Stricker, Scott Cookson, Matthew R. Bennett, William H. Mather, Lev S. Tsimring and Jeff Hasty ()
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Jesse Stricker: University of California, San Diego, La Jolla, California 92093, USA
Scott Cookson: University of California, San Diego, La Jolla, California 92093, USA
Matthew R. Bennett: University of California, San Diego, La Jolla, California 92093, USA
William H. Mather: University of California, San Diego, La Jolla, California 92093, USA
Lev S. Tsimring: Institute for Nonlinear Science, University of California, San Diego, La Jolla, California 92093, USA
Jeff Hasty: University of California, San Diego, La Jolla, California 92093, USA

Nature, 2008, vol. 456, issue 7221, 516-519

Abstract: A tunable synthetic gene oscillator Synthetic biologists aim to apply well-known principles of gene regulation to build living systems with desired properties, but practical applications have been disappointing. Jeff Hasty and colleagues have now combined microfluidics, single-cell microscopy and computational modelling to develop a bacterial gene oscillator that is fast, robust, persistent and whose frequency can be tuned externally. Their combination of experimental and theoretical work reveals a simplified oscillator design without the need for positive feedback.

Date: 2008
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DOI: 10.1038/nature07389

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