Lymphoid tissue genesis induced by commensals through NOD1 regulates intestinal homeostasis

Djahida Bouskra, Christophe Brézillon, Marion Bérard, Catherine Werts, Rosa Varona, Ivo Gomperts Boneca and Gérard Eberl ()
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Djahida Bouskra: Institut Pasteur, Laboratory of Lymphoid Tissue Development, CNRS, URA1961,
Christophe Brézillon: Institut Pasteur, Laboratoire des Bactéries Pathogènes Entériques,
Marion Bérard: Institut Pasteur, Animalerie Centrale
Catherine Werts: Institut Pasteur, Group of Biology and Genetics of the Bacterial Cell Wall, 25 rue du Dr Roux, Paris 75724, France
Rosa Varona: Centro Nacional de Biotecnologia/CSIC, UAM Campus Cantoblanco
Ivo Gomperts Boneca: Institut Pasteur, Group of Biology and Genetics of the Bacterial Cell Wall, 25 rue du Dr Roux, Paris 75724, France
Gérard Eberl: Institut Pasteur, Laboratory of Lymphoid Tissue Development, CNRS, URA1961,

Nature, 2008, vol. 456, issue 7221, 507-510

Abstract: ILF preservation Isolated lymphoid follicles (ILFs) are areas of specialized lymphoid tissue found in the lining of the small intestine where they are involved in protecting the host from invading pathogens. A new study of the composition of ILFs and the factors required for their formation has found that they are induced in the mouse small intestine by the presence of peptidoglycan from Gram-negative bacteria via recognition by the NOD1 innate receptor in epithelia cells. ILFs range from clusters of a few B cells to well-organized lymphoid nodules. Once established, the ILFs exert control over the make-up of the bacterial community. This rare example of microbe-induced tissue genesis in mammals demonstrates how a constructive 'dialogue' between bacteria and host can contribute to efficient digestion and protection from intestinal pathogens.

Date: 2008
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DOI: 10.1038/nature07450

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