Total synthesis of bryostatin 16 using atom-economical and chemoselective approaches

Barry M. Trost () and Guangbin Dong
Additional contact information
Barry M. Trost: Stanford University, Stanford, California 94305-5080, USA
Guangbin Dong: Stanford University, Stanford, California 94305-5080, USA

Nature, 2008, vol. 456, issue 7221, 485-488

Abstract: Economical with the atoms The ideal in organic synthesis is to prepare complex molecules in the smallest possible number of steps. Also important is atom economy — limiting waste by ensuring that most of atoms present in the reactants end up in the product. Barry Trost and Guangbin Dong demonstrate these principles to good effect in a synthesis of the naturally occurring compound bryostatin 16 that takes about half as many steps as previous methods. A key reaction is the formation of a large ring, in a palladium-catalysed reaction between two alkynes (hydrocarbons containing carbon-carbon triple bonds). The bryostatins, a group of macrolide lactones originally isolated from coral-like marine organisms, display a range of biological activities including cytotoxicity, and have potential in anticancer and memory enhancement therapies.

Date: 2008
References: Add references at CitEc
Citations:

Downloads: (external link)
https://www.nature.com/articles/nature07543 Abstract (text/html)
Access to the full text of the articles in this series is restricted.

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:nature:v:456:y:2008:i:7221:d:10.1038_nature07543

Ordering information: This journal article can be ordered from
https://www.nature.com/

DOI: 10.1038/nature07543

Access Statistics for this article

Nature is currently edited by Magdalena Skipper

More articles in Nature from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().