Sox18 induces development of the lymphatic vasculature in mice

Mathias François, Andrea Caprini, Brett Hosking, Fabrizio Orsenigo, Dagmar Wilhelm, Catherine Browne, Karri Paavonen, Tara Karnezis, Ramin Shayan, Meredith Downes, Tara Davidson, Desmond Tutt, Kathryn S. E. Cheah, Steven A. Stacker, George E. O. Muscat, Marc G. Achen, Elisabetta Dejana () and Peter Koopman ()
Additional contact information
Mathias François: Institute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland 4072, Australia
Andrea Caprini: IFOM, FIRC Institute of Molecular Oncology, Via Adamello 16, 20139 Milan, Italy
Brett Hosking: Institute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland 4072, Australia
Fabrizio Orsenigo: IFOM, FIRC Institute of Molecular Oncology, Via Adamello 16, 20139 Milan, Italy
Dagmar Wilhelm: Institute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland 4072, Australia
Catherine Browne: Institute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland 4072, Australia
Karri Paavonen: Ludwig Institute for Cancer Research, PO Box 2008, Royal Melbourne Hospital
Tara Karnezis: Ludwig Institute for Cancer Research, PO Box 2008, Royal Melbourne Hospital
Ramin Shayan: Ludwig Institute for Cancer Research, PO Box 2008, Royal Melbourne Hospital
Meredith Downes: Institute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland 4072, Australia
Tara Davidson: Institute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland 4072, Australia
Desmond Tutt: Institute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland 4072, Australia
Kathryn S. E. Cheah: Development & Growth, University of Hong Kong, Pokfulam, Hong Kong, China
Steven A. Stacker: Ludwig Institute for Cancer Research, PO Box 2008, Royal Melbourne Hospital
George E. O. Muscat: Institute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland 4072, Australia
Marc G. Achen: Ludwig Institute for Cancer Research, PO Box 2008, Royal Melbourne Hospital
Elisabetta Dejana: IFOM, FIRC Institute of Molecular Oncology, Via Adamello 16, 20139 Milan, Italy
Peter Koopman: Institute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland 4072, Australia

Nature, 2008, vol. 456, issue 7222, 643-647

Abstract: Sox18 as a lymphatic switch Mutations in the Sox18 transcription factor gene cause lymphatic dysfunction in the rare human syndrome hypotrichosis-lymphoedema-telangiectasia, suggesting that it may play a role in lymphatic development of function. That role has now been identified: Sox18 acts as a molecular switch to induce differentiation of lymphatic endothelial cells via the direct activation of transcription of the Prox1 lymphatic marker in lymphatic precursor cells of the embryonic venous system. This suggests possible new strategies for therapeutic stimulation or suppression of lymphoangiogenesis.

Date: 2008
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DOI: 10.1038/nature07391

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