Direct control of paralysed muscles by cortical neurons

Chet T. Moritz (), Steve I. Perlmutter and Eberhard E. Fetz
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Chet T. Moritz: University of Washington, Seattle, Washington 98195, USA
Steve I. Perlmutter: University of Washington, Seattle, Washington 98195, USA
Eberhard E. Fetz: University of Washington, Seattle, Washington 98195, USA

Nature, 2008, vol. 456, issue 7222, 639-642

Abstract: Neuromotor prosthetics: recruiting novel neurons Brain–machine interfaces are a promising approach for treating paralysis due to spinal cord injury, by rerouting control signals from the brain to the muscles. Previous work showed that monkeys can be trained to move robotic arms using signals from electrodes implanted in the brain. Now it is reported that monkeys can learn to move a temporarily paralysed wrist using signals artificially routed from single neurons in the brain that had not previously been associated with that movement. This may have significant implications for future design of brain–machine interfaces, which have traditionally relied on the activity of dedicated populations of neurons.

Date: 2008
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DOI: 10.1038/nature07418

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