Role for perinuclear chromosome tethering in maintenance of genome stability

Karim Mekhail, Jan Seebacher, Steven P. Gygi and Danesh Moazed ()
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Karim Mekhail: Howard Hughes Medical Institute and,
Jan Seebacher: Harvard Medical School, Boston, Massachusetts 02115, USA
Steven P. Gygi: Harvard Medical School, Boston, Massachusetts 02115, USA
Danesh Moazed: Howard Hughes Medical Institute and,

Nature, 2008, vol. 456, issue 7222, 667-670

Abstract: Chromsomes tethered for stability Suppressing the homologous recombination of repetitive DNA sequences is important for maintaining genome stability, and packaging of repeat DNA into silent chromatin was generally thought to protect it from recombination. Here, yeast ribosomal DNA (rDNA) repetitive sequences are shown to associate with the nuclear periphery via inner nuclear membrane proteins, and this tethering is required for rDNA stability. Sir2-dependent silencing is not sufficient to inhibit rDNA recombination. The inner nuclear membrane proteins involved are conserved and have been implicated in chromosome organization in metazoans. These results therefore reveal an ancient mechanism in which interactions between inner nuclear membrane proteins and chromosomal proteins ensure genome stability.

Date: 2008
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DOI: 10.1038/nature07460

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