Generation of a prostate from a single adult stem cell

Kevin G. Leong, Bu-Er Wang, Leisa Johnson and Wei-Qiang Gao ()
Additional contact information
Kevin G. Leong: Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, USA
Bu-Er Wang: Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, USA
Leisa Johnson: Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, USA
Wei-Qiang Gao: Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, USA

Nature, 2008, vol. 456, issue 7223, 804-808

Abstract: Regenerative medicine: prostate seeded by a single stem cell In mice exposed to repeated cycles of androgen deprivation and androgen replacement, the prostate gland shrinks and regenerates repeatedly. This suggested the existence of prostate stem cells; various cell-surface markers have been reported to identify candidate stem cells, however they are not specific for prostate stem cells. Leong et al. now report the identification of the cytokine receptor CD117 (also called c-kit or stem cell factor receptor) as a marker of a rare adult mouse prostate stem cell population. Using this marker, in combination with others, they isolate single cells that can generate a functioning prostate when transplanted into living mice.

Date: 2008
References: Add references at CitEc
Citations: View citations in EconPapers (1)

Downloads: (external link)
https://www.nature.com/articles/nature07427 Abstract (text/html)
Access to the full text of the articles in this series is restricted.

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:nature:v:456:y:2008:i:7223:d:10.1038_nature07427

Ordering information: This journal article can be ordered from
https://www.nature.com/

DOI: 10.1038/nature07427

Access Statistics for this article

Nature is currently edited by Magdalena Skipper

More articles in Nature from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().