FCA does not bind abscisic acid

Joanna M. Risk (), Richard C. Macknight () and Catherine L. Day ()
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Joanna M. Risk: University of Otago
Richard C. Macknight: University of Otago
Catherine L. Day: University of Otago

Nature, 2008, vol. 456, issue 7223, E5-E6

Abstract: Abstract Arising from: Fawzi A. Razem, Ashraf El-Kereamy, Suzanne R. Abrams & Robert D. Hill Nature 439, 290–294 (2006)10.1038/nature04373 The RNA-binding protein FCA promotes flowering in Arabidopsis1. Razem et al.2 reported that FCA is also a receptor for the phytohormone abscisic acid (ABA). However, we find that FCA does not bind ABA, suggesting that the quality of the proteins assayed and the sensitivity of the ABA-binding assay have led Razem et al. to erroneous conclusions. Because similar assays have been used to characterize other ABA receptors3,4, our results indicate that the ABA-binding properties of these proteins should be carefully re-evaluated and that alternative ABA receptors are likely to be discovered.

Date: 2008
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DOI: 10.1038/nature07646

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