Generation of cell polarity in plants links endocytosis, auxin distribution and cell fate decisions

Pankaj Dhonukshe (), Hirokazu Tanaka, Tatsuaki Goh, Kazuo Ebine, Ari Pekka Mähönen, Kalika Prasad, Ikram Blilou, Niko Geldner, Jian Xu, Tomohiro Uemura, Joanne Chory, Takashi Ueda, Akihiko Nakano, Ben Scheres and Jiří Friml ()
Additional contact information
Pankaj Dhonukshe: Faculty of Science, Utrecht University, Padualaan 8, 3584 CH, Utrecht, The Netherlands
Hirokazu Tanaka: VIB, Ghent University, Technologiepark 927, 9052 Gent, Belgium
Tatsuaki Goh: Graduate School of Science, University of Tokyo, Bunkyo-ku, Tokyo 113-0033, Japan
Kazuo Ebine: Graduate School of Science, University of Tokyo, Bunkyo-ku, Tokyo 113-0033, Japan
Ari Pekka Mähönen: Faculty of Science, Utrecht University, Padualaan 8, 3584 CH, Utrecht, The Netherlands
Kalika Prasad: Faculty of Science, Utrecht University, Padualaan 8, 3584 CH, Utrecht, The Netherlands
Ikram Blilou: Faculty of Science, Utrecht University, Padualaan 8, 3584 CH, Utrecht, The Netherlands
Niko Geldner: University of Lausanne, UNIL-Sorge, Biophore Building, 1015 Lausanne, Switzerland
Jian Xu: Faculty of Science, Utrecht University, Padualaan 8, 3584 CH, Utrecht, The Netherlands
Tomohiro Uemura: Graduate School of Science, University of Tokyo, Bunkyo-ku, Tokyo 113-0033, Japan
Joanne Chory: Plant Biology Laboratory, The Salk Institute for Biological Studies, La Jolla, California 92037, USA
Takashi Ueda: Graduate School of Science, University of Tokyo, Bunkyo-ku, Tokyo 113-0033, Japan
Akihiko Nakano: Graduate School of Science, University of Tokyo, Bunkyo-ku, Tokyo 113-0033, Japan
Ben Scheres: Faculty of Science, Utrecht University, Padualaan 8, 3584 CH, Utrecht, The Netherlands
Jiří Friml: VIB, Ghent University, Technologiepark 927, 9052 Gent, Belgium

Nature, 2008, vol. 456, issue 7224, 962-966

Abstract: Auxin transport: polarity and cell fate The polar transport of the plant hormone auxin is dependent on the localization of its efflux carriers called PINs. At present the mechanism mediating polarity of PIN proteins within cells remains unclear. In this study, Dhonuske et al. suggest a two-step mechanism generating PIN polarity. PINs are first targeted to the plasma membrane in a non-polar manner. Polarity is established in subsequent step involving internalization and recycling. Interference with endocytosis results in the loss of PIN polarity leading to a perturbation in auxin gradients. Abnormal accumulation of auxin results in various developmental defects as well as cell fate changes. This study reveals a connection between vesicle trafficking, establishment of polarity and gradient-based patterning in plants.

Date: 2008
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DOI: 10.1038/nature07409

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