Experience with moving visual stimuli drives the early development of cortical direction selectivity

Ye Li, Stephen D. Van Hooser, Mark Mazurek, Leonard E. White and David Fitzpatrick ()
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Ye Li: Duke University School of Medicine
Stephen D. Van Hooser: Duke University School of Medicine
Mark Mazurek: Duke University School of Medicine
Leonard E. White: Duke University School of Medicine
David Fitzpatrick: Duke University School of Medicine

Nature, 2008, vol. 456, issue 7224, 952-956

Abstract: Cortical development: following the light Neural circuits in the visual cortex are immature at birth, and require exposure to visual stimuli to form the connections and selectivity of the mature visual system. To date, just how stimulus driven neural activity guides the emergence of properties such as direction selectivity has been unclear. Li et al. now track this process with a combination of intrinsic and two-photon calcium imaging in visually naive ferrets. After exposing the animals to stimuli moving along one single axis of motion, they find that selectivity for those directions emerges rapidly as well as the local organization of direction preference between neighbouring cells.

Date: 2008
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DOI: 10.1038/nature07417

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