Contact inhibition of locomotion in vivo controls neural crest directional migration

Carlos Carmona-Fontaine, Helen K. Matthews, Sei Kuriyama, Mauricio Moreno, Graham A. Dunn, Maddy Parsons, Claudio D. Stern and Roberto Mayor ()
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Carlos Carmona-Fontaine: University College London
Helen K. Matthews: University College London
Sei Kuriyama: University College London
Mauricio Moreno: University College London
Graham A. Dunn: King’s College London
Maddy Parsons: King’s College London
Claudio D. Stern: University College London
Roberto Mayor: University College London

Nature, 2008, vol. 456, issue 7224, 957-961

Abstract: Close cellular encounters: neural crest cells prove a point The phenomenon of contact inhibition of cell movement (or locomotion) was first identified more than 50 years ago in fibroblast cells in vitro, and defective contact inhibition is suggested as a factor in malignant cell invasiveness. It occurs when two cells touch; they retract their protrusions and change their direction of movement. But the molecular basis of this inhibition, and whether it happens in vivo, are still matters of controversy. Now time-lapse microscopy of neural crest cells, highly migratory cells of embryonic origin, has been used to demonstrate contact inhibition of locomotion both in vivo and in vitro, and that it can account for their directional migration. But when a neural crest cell meets another cell type it fails to display contact inhibition of locomotion, allowing it to invade the tissue.

Date: 2008
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DOI: 10.1038/nature07441

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