X-ray structure of NS1 from a highly pathogenic H5N1 influenza virus

Zachary A. Bornholdt and B. V. Venkataram Prasad ()
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Zachary A. Bornholdt: Department of Molecular Virology and Microbiology,
B. V. Venkataram Prasad: Department of Molecular Virology and Microbiology,

Nature, 2008, vol. 456, issue 7224, 985-988

Abstract: Avian flu virulence The NS1 protein of influenza virus is a critical virulence factor that antagonizes the host antiviral response by multiple mechanisms, including the binding and sequestration of double-stranded RNA. The structure of full-length NS1 protein has now been determined using samples from a virulent H5N1 avian influenza virus strain isolated during a 2004 Vietnamese 'bird flu' outbreak. The molecule's RNA binding domain shows subtle differences when compared to that in non-H5N1 strains whereas the effector domain is significantly altered. The two domains interact in such a way as to form tubules that may act to sequester dsRNA, allowing the virus to evade the host's innate immune response.

Date: 2008
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DOI: 10.1038/nature07444

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