G protein Gαi functions immediately downstream of Smoothened in Hedgehog signalling

Stacey K. Ogden, Dennis Liang Fei, Neal S. Schilling, Yashi F. Ahmed, John Hwa and David J. Robbins ()
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Stacey K. Ogden: Department of Pharmacology and Toxicology,
Dennis Liang Fei: Department of Pharmacology and Toxicology,
Neal S. Schilling: Department of Pharmacology and Toxicology,
Yashi F. Ahmed: Department of Genetics,
John Hwa: Department of Pharmacology and Toxicology,
David J. Robbins: Department of Pharmacology and Toxicology,

Nature, 2008, vol. 456, issue 7224, 967-970

Abstract: Hedgehog signalling: the role of G proteins Whether G proteins might play a role in Hedgehog (Hh) signal transduction has been controversial. Here, the seven-domain transmembrane protein Smoothened (Smo) is shown to activate a G protein, Gαi, to modulate intracellular cyclic AMP levels in response to Hh.

Date: 2008
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DOI: 10.1038/nature07459

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