Structural recognition and functional activation of FcγR by innate pentraxins

Jinghua Lu, Lorraine L. Marnell, Kristopher D. Marjon, Carolyn Mold, Terry W. Du Clos and Peter D. Sun ()
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Jinghua Lu: Structural Immunology Section, Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Maryland 20852, USA
Lorraine L. Marnell: University of New Mexico, Albuquerque, New Mexico 87131, USA
Kristopher D. Marjon: University of New Mexico, Albuquerque, New Mexico 87131, USA
Carolyn Mold: University of New Mexico, Albuquerque, New Mexico 87131, USA
Terry W. Du Clos: University of New Mexico, Albuquerque, New Mexico 87131, USA
Peter D. Sun: Structural Immunology Section, Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Maryland 20852, USA

Nature, 2008, vol. 456, issue 7224, 989-992

Abstract: Pentraxins involved in FcγR activation The classical pentraxins, serum amyloid P component (SAP) and C-reactive protein (CRP), are major acute phase reactants in mouse and man. As shown in this paper, pentraxins recognize various FcγRs, and SAP opsonization activates FcγR-mediated phagocytosis and cytokine secretion. The receptor binding sites for SAP and IgG overlap resulting in competition of IgG binding to FcγR as well as inhibition of immune complex-mediated phagocytosis by soluble pentraxins.

Date: 2008
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DOI: 10.1038/nature07468

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