Endonucleolytic RNA cleavage by a eukaryotic exosome

Alice Lebreton, Rafal Tomecki, Andrzej Dziembowski () and Bertrand Séraphin ()
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Alice Lebreton: Equipe Labellisée La Ligue, Centre de Génétique Moléculaire, CNRS UPR 2167, 91198 Gif-sur-Yvette, France
Rafal Tomecki: Faculty of Biology, University of Warsaw
Andrzej Dziembowski: Faculty of Biology, University of Warsaw
Bertrand Séraphin: Equipe Labellisée La Ligue, Centre de Génétique Moléculaire, CNRS UPR 2167, 91198 Gif-sur-Yvette, France

Nature, 2008, vol. 456, issue 7224, 993-996

Abstract: RNA processing: a dual role exosome The exosome is a multisubunit exonuclease complex that degrades many types of RNAs, in many different contexts, in a 3' to 5' manner. The catalytic component of the exosome is the Dis3 subunit. Dis3 contains a PIN domain, which is sometimes associated with nuclease activity. In this work, Lebreton et al. show that the Dis3 PIN domain possesses endonuclease activity (that is, it can cleave RNA internally, rather than from an end). Mutations in either this domain or in the exonuclease domain exhibit a growth phenotype, suggesting that both activities are physiologically important. While other RNase complexes contain both endo- and exonuclease activities, this is the first example of both activities being encoded in a single protein.

Date: 2008
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DOI: 10.1038/nature07480

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