Highly efficient molybdenum-based catalysts for enantioselective alkene metathesis

Steven J. Malcolmson, Simon J. Meek, Elizabeth S. Sattely, Richard R. Schrock and Amir H. Hoveyda ()
Additional contact information
Steven J. Malcolmson: Merkert Chemistry Center, Boston College, Chestnut Hill, Massachusetts 02467, USA
Simon J. Meek: Merkert Chemistry Center, Boston College, Chestnut Hill, Massachusetts 02467, USA
Elizabeth S. Sattely: Merkert Chemistry Center, Boston College, Chestnut Hill, Massachusetts 02467, USA
Richard R. Schrock: Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
Amir H. Hoveyda: Merkert Chemistry Center, Boston College, Chestnut Hill, Massachusetts 02467, USA

Nature, 2008, vol. 456, issue 7224, 933-937

Abstract: A new chiral catalyst Alkene metathesis (also called olefin metathesis or transalkylidenation) is an organic reaction widely used to synthesize products including medicines, polymers and fuels. Its importance was recognized in 2005, when Yves Chauvin, Robert Grubbs and Richard Schrock shared the Nobel prize for work on metathesis. A new class of molybdenum-based chiral catalyst, capable of initiating alkene metathesis with exceptional efficiency and enantioselectivity, is reported in this issue. The new catalysts bear a stereogenic metal centre and carry only monodentate ligands. Their effectiveness was demonstrated in an enantioselective synthesis of the Aspidosperma alkaloid, quebrachamine, via a metathesis reaction that cannot be promoted by any of the previously reported catalysts.

Date: 2008
References: Add references at CitEc
Citations:

Downloads: (external link)
https://www.nature.com/articles/nature07594 Abstract (text/html)
Access to the full text of the articles in this series is restricted.

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:nature:v:456:y:2008:i:7224:d:10.1038_nature07594

Ordering information: This journal article can be ordered from
https://www.nature.com/

DOI: 10.1038/nature07594

Access Statistics for this article

Nature is currently edited by Magdalena Skipper

More articles in Nature from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().