Live-animal tracking of individual haematopoietic stem/progenitor cells in their niche

Cristina Lo Celso, Heather E. Fleming, Juwell W. Wu, Cher X. Zhao, Sam Miake-Lye, Joji Fujisaki, Daniel Côté, David W. Rowe, Charles P. Lin () and David T. Scadden ()
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Cristina Lo Celso: Center for Regenerative Medicine and,
Heather E. Fleming: Center for Regenerative Medicine and,
Juwell W. Wu: Advanced Microscopy Program, Center for Systems Biology and Wellman Center for Photomedicine, Massachusetts General Hospital, 185 Cambridge Street, Boston, Massachusetts 02114, USA
Cher X. Zhao: Center for Regenerative Medicine and,
Sam Miake-Lye: Center for Regenerative Medicine and,
Joji Fujisaki: Advanced Microscopy Program, Center for Systems Biology and Wellman Center for Photomedicine, Massachusetts General Hospital, 185 Cambridge Street, Boston, Massachusetts 02114, USA
Daniel Côté: Advanced Microscopy Program, Center for Systems Biology and Wellman Center for Photomedicine, Massachusetts General Hospital, 185 Cambridge Street, Boston, Massachusetts 02114, USA
David W. Rowe: University of Connecticut Health Center, 663 Farmington Avenue, Farmington, Connecticut 06030, USA
Charles P. Lin: Advanced Microscopy Program, Center for Systems Biology and Wellman Center for Photomedicine, Massachusetts General Hospital, 185 Cambridge Street, Boston, Massachusetts 02114, USA
David T. Scadden: Center for Regenerative Medicine and,

Nature, 2009, vol. 457, issue 7225, 92-96

Abstract: A bone-marrow niche Haematopoietic stem cells are found in a specialized regulatory environment or niche in bone marrow. The precise location and characteristics of this niche are now made clearer by two sophisticated imaging studies. Lo Celso et al. performed live-animal tracking of individual haematopoietic cells and find that osteoblasts are enmeshed in microvessels and that different haematopoietic cell populations are localized in different areas according to their stage of differentiation. Xie et al. used newly developed ex vivo real-time imaging technology and immunoassays to trace the homing of fluorescently labelled haematopoietic stem cells in response to irradiation. They report that the membrane lining the medullary cavity of bone forms a special zone that normally maintains haematopoietic stem cells, but promotes their expansion in response to bone marrow damage.

Date: 2009
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DOI: 10.1038/nature07434

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