X-ray structure of a pentameric ligand-gated ion channel in an apparently open conformation

Nicolas Bocquet, Hugues Nury, Marc Baaden, Chantal Le Poupon, Jean-Pierre Changeux, Marc Delarue () and Pierre-Jean Corringer ()
Additional contact information
Nicolas Bocquet: Pasteur Institute, G5 Group of Channel-Receptor, CNRS URA 2182
Hugues Nury: Pasteur Institute, G5 Group of Channel-Receptor, CNRS URA 2182
Marc Baaden: Institut de Biologie Physico-Chimique, CNRS UPR 9080, 75005 Paris, France
Chantal Le Poupon: Pasteur Institute, G5 Group of Channel-Receptor, CNRS URA 2182
Jean-Pierre Changeux: Pasteur Institute, CNRS URA 2182, F75015, Paris, France
Marc Delarue: Pasteur Institute, Unit of Structural Dynamics of Macromolecules, CNRS URA 2185
Pierre-Jean Corringer: Pasteur Institute, G5 Group of Channel-Receptor, CNRS URA 2182

Nature, 2009, vol. 457, issue 7225, 111-114

Abstract: ELIC channel structure Recently, the first crystal structure of a pentameric ligand-gated ion channel known as GLIC was published, which represented a closed state of the channel. Two papers in this issue report the crystal structures of the presumptive open states of a related channel — ELIC —and show significant tilting of the M2 and M3 α-helices from the closed state.

Date: 2009
References: Add references at CitEc
Citations: View citations in EconPapers (5)

Downloads: (external link)
https://www.nature.com/articles/nature07462 Abstract (text/html)
Access to the full text of the articles in this series is restricted.

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:nature:v:457:y:2009:i:7225:d:10.1038_nature07462

Ordering information: This journal article can be ordered from
https://www.nature.com/

DOI: 10.1038/nature07462

Access Statistics for this article

Nature is currently edited by Magdalena Skipper

More articles in Nature from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().