Detection of functional haematopoietic stem cell niche using real-time imaging

Yucai Xie, Tong Yin, Winfried Wiegraebe, Xi C. He, Diana Miller, Danny Stark, Katherine Perko, Richard Alexander, Joel Schwartz, Justin C. Grindley, Jungeun Park, Jeff S. Haug, Joshua P. Wunderlich, Hua Li, Simon Zhang, Teri Johnson, Ricardo A. Feldman () and Linheng Li ()
Additional contact information
Yucai Xie: Stowers Institute for Medical Research, 1000 E. 50th Street, Kansas City, Missouri 64110, USA
Tong Yin: Stowers Institute for Medical Research, 1000 E. 50th Street, Kansas City, Missouri 64110, USA
Winfried Wiegraebe: Stowers Institute for Medical Research, 1000 E. 50th Street, Kansas City, Missouri 64110, USA
Xi C. He: Stowers Institute for Medical Research, 1000 E. 50th Street, Kansas City, Missouri 64110, USA
Diana Miller: and Greenebaum Cancer Center, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
Danny Stark: Stowers Institute for Medical Research, 1000 E. 50th Street, Kansas City, Missouri 64110, USA
Katherine Perko: Stowers Institute for Medical Research, 1000 E. 50th Street, Kansas City, Missouri 64110, USA
Richard Alexander: Stowers Institute for Medical Research, 1000 E. 50th Street, Kansas City, Missouri 64110, USA
Joel Schwartz: Stowers Institute for Medical Research, 1000 E. 50th Street, Kansas City, Missouri 64110, USA
Justin C. Grindley: Stowers Institute for Medical Research, 1000 E. 50th Street, Kansas City, Missouri 64110, USA
Jungeun Park: Stowers Institute for Medical Research, 1000 E. 50th Street, Kansas City, Missouri 64110, USA
Jeff S. Haug: Stowers Institute for Medical Research, 1000 E. 50th Street, Kansas City, Missouri 64110, USA
Joshua P. Wunderlich: Stowers Institute for Medical Research, 1000 E. 50th Street, Kansas City, Missouri 64110, USA
Hua Li: Stowers Institute for Medical Research, 1000 E. 50th Street, Kansas City, Missouri 64110, USA
Simon Zhang: Stowers Institute for Medical Research, 1000 E. 50th Street, Kansas City, Missouri 64110, USA
Teri Johnson: Stowers Institute for Medical Research, 1000 E. 50th Street, Kansas City, Missouri 64110, USA
Ricardo A. Feldman: and Greenebaum Cancer Center, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
Linheng Li: Stowers Institute for Medical Research, 1000 E. 50th Street, Kansas City, Missouri 64110, USA

Nature, 2009, vol. 457, issue 7225, 97-101

Abstract: A bone-marrow niche Haematopoietic stem cells are found in a specialized regulatory environment or niche in bone marrow. The precise location and characteristics of this niche are now made clearer by two sophisticated imaging studies. Lo Celso et al. performed live-animal tracking of individual haematopoietic cells and find that osteoblasts are enmeshed in microvessels and that different haematopoietic cell populations are localized in different areas according to their stage of differentiation. Xie et al. used newly developed ex vivo real-time imaging technology and immunoassays to trace the homing of fluorescently labelled haematopoietic stem cells in response to irradiation. They report that the membrane lining the medullary cavity of bone forms a special zone that normally maintains haematopoietic stem cells, but promotes their expansion in response to bone marrow damage.

Date: 2009
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DOI: 10.1038/nature07639

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