Frequent in-frame somatic deletions activate gp130 in inflammatory hepatocellular tumours

Sandra Rebouissou, Mohamed Amessou, Gabrielle Couchy, Karine Poussin, Sandrine Imbeaud, Camilla Pilati, Tina Izard, Charles Balabaud, Paulette Bioulac-Sage and Jessica Zucman-Rossi ()
Additional contact information
Sandra Rebouissou: Inserm, U674, Génomique fonctionnelle des tumeurs solides, Paris F-75010, France
Mohamed Amessou: Inserm, U674, Génomique fonctionnelle des tumeurs solides, Paris F-75010, France
Gabrielle Couchy: Inserm, U674, Génomique fonctionnelle des tumeurs solides, Paris F-75010, France
Karine Poussin: Inserm, U674, Génomique fonctionnelle des tumeurs solides, Paris F-75010, France
Sandrine Imbeaud: Array s/IMAGE, Genexpress, Functional Genomics and Systems Biology for Health, UMR 7091 CNRS; Université Paris 6 Pierre et Marie Curie
Camilla Pilati: Inserm, U674, Génomique fonctionnelle des tumeurs solides, Paris F-75010, France
Tina Izard: The Scripps Research Institute, Jupiter, Florida 33458, USA
Charles Balabaud: Inserm, U889; Université Victor Segalen Bordeaux 2, IFR66, Bordeaux F-33076, France
Paulette Bioulac-Sage: Inserm, U889; Université Victor Segalen Bordeaux 2, IFR66, Bordeaux F-33076, France
Jessica Zucman-Rossi: Inserm, U674, Génomique fonctionnelle des tumeurs solides, Paris F-75010, France

Nature, 2009, vol. 457, issue 7226, 200-204

Abstract: Inflammation and cancer It is know that there is a link between some types of chronic inflammation and certain cancers. Now a genetic study of liver tumour tissues has identified gain-of-function mutations in the IL6ST gene, part of an inflammatory signalling pathway that codes for the interleukin-6 co-receptor gp130, as a possible early step on the development of benign liver tumours. This mutation in IL6ST was frequently found together with mutations in β-catenin, suggesting that they may cooperate in promoting tumorigenesis.

Date: 2009
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DOI: 10.1038/nature07475

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